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The Degradation Behavior and Surface Modification of Calcium Phosphate Based Porous Bioglass-ceramic Scaffolds

Author: LiXuDong
Tutor: CaiShu
School: Tianjin University
Course: Materials Science and Engineering
Keywords: Calcium and phosphorus biological glass ceramic Strontium-doped Ca4P6O19 Solubility Surface Modification
CLC: R318.08
Type: Master's thesis
Year: 2010
Downloads: 45
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Abstract


The calcium and phosphorus bio-glass ceramic material as the ideal bone tissue replacement and a pharmaceutical carrier material, not only because of its chemical composition and bone inorganic similar, because after its implantation in the human body can be completely degraded by the new bone tissue replaced. And in order to meet its final application, by changing the chemical composition, heat treatment temperature, to control the phase of crystallization to adjust its solubility. In this paper, the sol-gel method CaO-P 2 O 5 -Na 2 O-of SrO-MgO-HA bioglass ceramic powder for powder, organic foam prepared by impregnation porous scaffolds and surface modification of the glass ceramic scaffold materials in different the pH (1.0,3.0,10.0). By XRD, SEM, ion concentration, degradability and cell experiments to study the addition of the HA precursor glass ceramic crystallization, morphology, and heat treatment temperature on the mechanical properties of the stent. Evaluate the degradation of performance, and the pH value of the glass ceramic brackets in simulated body fluid (SBF) investigated the effect of the surface modification of surface modification on cell adhesion. Experimental results show that the HA precursor added, on the one hand, with the β-Ca 2 P 2 O 7 in the heat treatment during the reaction, the generated the main crystalline phase Ca 4 P 6 O 19 and the other hand, as a nucleating agent, can be induced Ca 7 Sr 3 (PO 4 ) 6 (OH) 2 new phase generation, promotion of strontium isotopes into Ca < sub> 4 P 6 O 19 lattice. The stomata was 72.8% in the stent, the compressive strength of up to 8.46 MPa, basically meet the requirements of cancellous bone bearer. The strontium to enter Ca 4 P 6 O 19 lattice, greatly improve the solubility of the crystallization phase; same time as Ca 7 Sr 3 (PO 4 ) 6 (OH) 2 dissolution of apatite The precipitation provides nucleation sites, which greatly improves the biological activity of the material. After pH 3.0,10.0 modified material surface to generate a new layer CaP2O6, amorphous Ca 3 (as PO in 4 ) 2 · nH 2 O layer, not only to improve the roughness of the surface of the stent, and can promote the formation of the apatite layer to improve the performance of the degradation of the scaffolds in SBF by pH 10.0 modified effect more significant. Cell experiments bioactive glass ceramic brackets indicate that the system has its main crystalline phase Ca 4 P 6 O 19 good biofacies capacitive significantly change performance by the pH 10.0 provide a scaffold for cell adhesion.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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