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Quinolinic Acid Effect on the Ca2+ Currents of NMDA Receptor on the Spiral Ganglion Cells

Author: ZhengNa
Tutor: XiaoHongJun；KongWeiJia
School: Huazhong University of Science and Technology
Course: Department of Otolaryngology,
Keywords: Spiral ganglion cells Patch clamp NMDA receptor Quinolinic acid DM ( dextromethorphan hydrobromide )
CLC: R96
Type: Master's thesis
Year: 2010
Downloads: 22
Quote: 0
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Abstract


Objective: quinolinic acid NMDA receptors in the spiral ganglion cells Ca 2 < / sup > angle of the impact of the current study quinolinic acid (quinolinic acid, QA) rat spiral ganglion cells (spiral ganglion cells SGC) neural excitotoxic mechanism . Of quinolinic acid in secretory otitis media ( of otitis media with effusion , OME ) induced sensorineural hearing loss (sensorineural hear loss, SNHL) in the role . Observed antagonism of DM ( dextromethorphan hydrobromide ) QA neural excitotoxicity . Method : newborn SD rats SGC primary cultured for 72 h after the patch clamp technique quinolinic acid concentration of the NMDA receptor Ca 2 < / sup > currents . Explored the the dextromethorphan hydrobromide DM QA activate NMDA receptor Ca of 2 the impact . Results: When the SGC , respectively, are exposed to the 150uM 200uM 250uM 3 the 5ul quinolinic acid solution , the NMDA mediated Ca 2 < / sup > current average current amplitude according to (x ± s) , respectively (-0.41 ± 1.1) nA (n = 39) and ( -0.62 ± 1.3 ) nA ( n = 39) and (-0.82 ± 1.5) nA (n = 39) DM make of QA activation of Ca 2 current amplitude reduced. Conclusion : excessive QA activation of the NMDA receptor on the cell membrane Ca 2 < / sup> current caused by rats in vitro culture SGC damage DM can reduce the toxic effects of QA nervous excitement of SGC .

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