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Studies on Piroxicam Organogels

Author: YangYanLi
Tutor: XuZuo
School: Shenyang Pharmaceutical University
Course: Pharmacy
Keywords: Organogel Rheology Drug release Percutaneous permeability Tissue distribution
CLC: R94
Type: Master's thesis
Year: 2008
Downloads: 55
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Abstract

Organogel is the continuous phase to the organic medium is a semi-solid system, generally referred to as oil gel or lipid gel when topically applied, as percutaneous administration, the carrier having a clear advantage is one of the research focus in recent years, with broad application prospects. The prepared the the amphiphilic organic gel, phospholipids organogel, Pluronic phospholipid organic gel other five kinds of organic gel, and carbopol hydrogel, evaluation of the rheological properties of the organic gel; to piroxicam and Piroxicam monoethanolamine salt as a model drug, investigated the organic gel vitro drug release and percutaneous permeability; piroxicam as a model drug, the organic phospholipid gel, Pluronic the phospholipids organic gel and carbomer local tissue distribution of the hydrogel. Applications the vertebral - board model, the oscillation mode and organic gel and carbomer hydrogel rheological parameters measured in the linear viscoelastic range. The results show that the amphiphilic organic gel and Pluronic phospholipid organic gel and hydrogel has a lower phase angle (≤ 30 °), and the viscous modulus and the elastic modulus, rendering the non-frequency-dependent, showing rheological characteristics of a typical gel; under ambient conditions, the phase angle of the phospholipid organogel, showing some of the characteristics of the viscous fluid; appropriate phase transition temperatures, good spreadability; except phospholipid organogel other The gel has a shear thinning nature. Franz diffusion cell method, using the improved use of nylon membrane permeable membrane of isolated rat abdominal skin to piroxicam and piroxicam single, ethanolamine salt as a model drug investigated the organic gel vitro release and percutaneous permeability. The results showed that the highest in vitro release Pluronic the phospholipids organic gel Piroxicam monoethanolamine salt 48h cumulative release percentage were 81.56 ± 3.09% and 66.21 ± 1.74%; phospholipids of organogel in vitro permeability best 48h piroxicam and its monoethanolamine salt accumulated through 43.52 ± 0.94% and 10.44 ± 1.30% percentage. Of piroxicam as the model drug was investigated after the local tissue distribution in the organogel of Pluronic phospholipids, phospholipids, organic gel, and carbopol hydrogel the three kinds gel rats administered topically. The results showed that the organic gels and hydrogels have a similar tissue distribution, the administration side skin C _max Pluronic phospholipid organogel (53.51 + of 28.90μg / g), followed hydrogels, phospholipids organogel minimum; administration side local tissue C _max higher, greater than the drug concentration of the plasma and contralateral same organization, the delivery side of the tissue (muscles and joints) / plasma organization greater than the same contralateral tissue / plasma ratio, the local organization of the administration side of the concentration-time curve were bimodal, indicating that piroxicam local absorption there are two ways, namely direct transparent and system cycle redistribution. Organic gel having a suitable rheological properties, strong drug loading capacity and drug percutaneous permeability, suitable as a carrier for percutaneous administration.

Studies on Piroxicam Organogels

Abstract

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