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The Relationship between the Expression of ΔNp73、P53、 P21waf-1 in Breast Invasive Ductal Cacinoma and 5 Years Survival Rate

Author: FanDanDan
Tutor: XingLuQi
School: Henan University of Science and Technology
Course: Pathology and Pathophysiology
Keywords: Breast invasive ductal carcinoma ΔNp73 p53 p21waf-1 Five-year survival
CLC: R737.9
Type: Master's thesis
Year: 2010
Downloads: 21
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Abstract


Objective: To study the invasive ductal breast cancer tissue in ΔNp73, p53, and p21waf-1 expression, and to discuss the relationship between the three expression and 5-year survival rate in patients and the clinical and pathological features. Methods: 79 cases of Pathology, the First Affiliated Hospital of Henan University of Science and Technology in January 1999 - 2003 December pathological data and follow-up of 5 years infiltrating ductal breast cancer cases, using immunohistochemical SP method to detect breast cancer tissue ΔNp73, p53, p21waf-1 protein expression, statistical analysis with SPSS16.0 software ΔNp73, p53,, p21waf-1 protein expression in breast cancer and the relationship with the 5-year survival and clinical and pathological features. Results: 1.ΔNp73 in the positive expression in the breast cancer rate is higher than the rate of expression in normal breast and breast fibroadenoma, a statistically significant difference; ΔNp73 protein expression and lymph node metastasis, and five-year survival rate, and patients age, the quadrant, pathology grade. 2. P53 positive expression in breast cancer is higher than the rate of expression in normal breast and breast fibroadenoma, the difference was statistically significant; p53 protein expression with histological grade, lymph node metastasis, and five-year survival rate quadrant, and the patient's age, has nothing to do. 3. P21 positive expression rate in breast cancer is lower than the rate of expression in normal breast and breast fibroadenoma, the difference was statistically significant; of p21 protein expression and the patient's age, the quadrant, lymph node metastasis, pathological sub- level and the five-year survival rate has nothing to do. 4.ΔNp73 expression of p53 in breast cancer, the expression of CD44V6 associated. the expression of p21 and ΔNp73 p53 expression is no correlation. 5 univariate survival analysis of factors affecting overall survival of breast cancer are age, axillary lymph node status, the ΔNp73 protein P53 protein, CD44V6 protein expression; factors do not affect the overall survival rate of histologic grading, P21 protein expression . Prognostic analysis of the results of the multivariate Cox proportional hazards model, the ΔNp73 expression level and lymph node metastasis, infiltrating ductal breast cancer prognosis independent factors. Conclusion: 1.ΔNp73 play a role in the occurrence of breast cancer, positive expression possibility of lymph node metastasis in patients with breast cancer, and the 5-year survival rate is lower. 2. P53 involved in the occurrence of breast cancer patients with positive lymph nodes prone to metastasis, 5-year survival rate after surgery dropped. 3. P21 may be associated with the formation of breast cancer, has little to do with the progression of breast cancer and late events. ΔNp73 and p53 breast may exist a common pathway the ΔNp73 and CD44V6 may exist in the mechanisms of breast cancer lymph node metastasis synergies and jointly affect the prognosis of patients. p21 is involved in breast cancer formation process may be through a non-p53 pathways play a role. Age, axillary lymph node metastasis status ΔNp73 protein, p53 protein expression, Expression of CD44V6 protein affect the overall survival of breast cancer; histological grade, P21 protein does not affect the overall survival. 6.ΔNp73 expression levels and lymph node metastasis as independent indicators to predict the prognosis of breast cancer.

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Breast tumor
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