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Study on the Mechanisms of Quercetin and Kaempferol Induced Apoptosis in the Human Leukemic Cells

Author: RenHuiJuan
Tutor: HanYanQiu；MengXueMin
School: Inner Mongolia Medical College
Course: Internal Medicine
Keywords: Quercetin Kaempferol HL-60 cell line Apoptosis
CLC: R733.71
Type: Master's thesis
Year: 2009
Downloads: 14
Quote: 0
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Abstract


Objective To study the the main ingredients of Choerospondiatis flavonoids quercetin and kaempferol anti -leukemia effect , to explore its possible mechanism of action . Quercetin and kaempferol inhibit the proliferation of HL-60 cells by MTT assay ; cycle of HL-60 cells by flow cytometry drugs induce apoptosis was observed by Western blot drug-induced survivin protein expression in HL-60 cells apoptosis . The main ingredients of Choerospondiatis flavonoids quercetin and kaempferol phenol significant anti-leukemia effect ; MTT method showed that quercetin and kaempferol significantly inhibited the growth of HL-60 cells , and a dose- and time dependence. Occurrence of G2 / M phase arrest and apoptosis of HL-60 cells by flow cytometry to administration . Western blot analysis showed that drug-induced HL-60 cells survivin protein downregulation . Conclusion wide main ingredients of jujube flavonoids quercetin and kaempferol phenol significant anti-leukemia effect , stronger than kaempferol and quercetin induced apoptosis , its mechanism of action may be through the inhibition of cell proliferation , cell cycle arrest , inhibition of survivin protein to induce apoptosis .

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CLC: > Medicine, health > Oncology > Hematopoietic and lymphoid neoplasms > Leukemia > Acute leukemia
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