Dissertation > Excellent graduate degree dissertation topics show

Three-dimension MRI and Diffusion Tensor Imaging Study on Brain Micro-structural Changes in Patients with Major Depressive Disorder

Author: LiuHaiYan
Tutor: YaoZhiJian
School: Nanjing Medical University
Course: Psychiatry and Mental Health
Keywords: Major Depression Three-dimensional structure NMR Diffusion tensor imaging Anisotropy values Neurocognitive
CLC: R749.4
Type: Master's thesis
Year: 2009
Downloads: 41
Quote: 0
Read: Download Dissertation

Abstract

Objective: application of the three-dimensional structure of nuclear magnetic resonance (3D) and diffusion tensor imaging (DTI), the United Wisconsin Card Sorting Test (WCST) neuropsychological tests to explore the young and middle-aged major depressive disorder (MDD) in patients with brain fine structure change and cognitive impairment, and to explore the relationship between the two. Methods: 70 cases of young and middle-aged patients with major depression (at the same time meet the CCMD-3 single-phase depression and DSM-IV major depression diagnostic criteria), age, gender, and educational level were 46 cases matched healthy controls, patients 24 item Hamilton Depression Rating Scale (HAMD24) ≥ 35, and the normal group lt; 8. Subjects enrolled 1.5T GE MRI system check, followed by conventional MRI the 3D and DTI scan, while the Wisconsin Card Sorting (WCST), verbal fluency (Fluency Test), color interference (Stroop Test ) and the number sign (Digital Symbol) neurocognitive evaluation. Patients scanned by conventional antidepressant treatment (not interfere with the types of antidepressant drugs) and 8 to 10 weeks of follow-up studies, some patients the (HAMD24 reduction rate ≥ 75%) above imaging studies (3D except check) and again neuropsychological tests. Results: A total of 70 patients and 35 normal subjects completed MRI scans and cognitive psychological tests, 29 patients completed the follow-up and review. Exclude the image quality problems caused by a variety of factors, uncooperative, and part of the age, years of education, there are statistical differences, statistical analysis of patients eventually enter the test data as follows: 62 cases of 3D data available [the first 28 patients (14 males, 14 females), 34 patients (18 males, 16 cases)] recurrence; 52 cases before the DTI therapy [the first 25 cases (male 14 cases, 11 females), recurrence of 27 cases (15 males, 12 females)] after treatment of 20 cases; 3D data of healthy controls were 28 cases (male 12 cases, 16 females), DTI data of 24 patients (12 males, 12 females). White matter density (WMC), mainly carried out on the data for statistical comparison between gray matter density (GMC) and anisotropic value (FA) group, is also briefly discussed cognitive changes, part of the imaging data with recognized The known correlation analysis was done. The results are as follows: a three-dimensional nuclear magnetic resonance results 1.1 depression patients and healthy controls comparison: the first recurrence (including male group and female group) were not reduced compared with normal control white matter or gray matter regions men recurrence group than men starting group in The left temporal gyrus gray matter density reduction, women relapse group compared with the women starting group reduced gray matter density in the left lingual gyrus and left frontal gyrus; 1.2 gender differences: the first group and the recurrence group were not found gender differences in gray matter or white matter density normal control group, more men than women in the left temporal gyrus gray matter density decreases (all P lt; 0.005, pixel threshold gt; 10). 2 Magnetic resonance diffusion tensor result of 2.1 in patients with depression and healthy controls comparison: the group of patients than the healthy control group mainly in the frontal lobe, temporal lobe and cingulate regions of white matter FA values ??decrease, specific performance in the first group (including men group and female group) back in the left frontal, left superior temporal gyrus, left temporal lobe next time and limbic cingulate FA value lower than the healthy control group, the recurrence group mainly in the right middle frontal gyrus, the right amount gyrus, bilateral frontal gyrus FA value lower than the healthy control group; further analysis found between the groups, male patients, relapse compared with the first group in the left middle frontal gyrus, the right middle frontal gyrus, left superior temporal gyrus and the right edge of the leaves cingulate FA value is further reduced in female patients, relapse compared with the first group in the left frontal gyrus and right temporal gyrus FA value further lower (all P lt; 0.001 pixel threshold gt; 10); 2.2 Gender DTI differences in study: women starting group in the left frontal medial frontal gyrus and left middle frontal gyrus region FA value lower than men starting group, women relapse group FA values ??in the right inferior frontal gyrus region reduce the recurrence group than men, while the women's health group than men's health group back in the right superior frontal, middle frontal gyrus, right frontal next time and the left temporal lobe next time the FA values ??inherent gender differences (all P lt; 0.001 pixel threshold gt; 20). 2.3 DTI compare before and after treatment: patients after treatment than before treatment in the right inferior frontal gyrus, the left edge of the leaf buckle back and the integrity of white matter fibers in the right occipital lobe gyrus elevated, but after the treatment group compared with the healthy control group in the bilateral The the limbic cingulate and frontal gyrus white matter integrity is still lower (P lt; 0.001, pixel threshold gt; 20), after the treatment of depression group WCST (Cc, Re, Rpe) scores, numbers, symbols and digit span ( positive) than before treatment improved significantly (P lt; 0.05), with the healthy control group differences were not found significant sex (P gt; 0.05). Conclusion: 1 the depression edge of the loop part of the region has not been involved in white quality change; longer course of recurrence in patients with frontal lobe gray matter density further reduce recurrent; brain tissue density of gender differences in brain pathology may not depression loop, among other factors. 2 young and middle-aged patients with major depression compared with normal control there is an edge - cortical neuronal circuits of nerve damage, mainly involving the frontal, temporal and cingulate areas of nerve fibers change the longer course, the onset of more times relapse patients, compared with the first part of the area of ??the depressed patients white matter fiber damage further aggravate; effective antidepressant treatment to improve cognitive function, white matter fibers, some degree of recovery, but compared with normal subjects, there is still a certain degree of damage the integrity of white matter fiber structure; groups there are gender differences in the female patient group (including starting and recurrence) compared to the damage to the nerve fibers of the group of male patients in a more serious condition, but limited to the study of the small sample size, the incidence and epidemiology contact with the extent to which gender differences need further study.

Related Dissertations

CLC: > Medicine, health > Neurology and psychiatry > Psychiatry > Affective psychosis
© 2012 www.DissertationTopic.Net Mobile