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Acute coronary events general purpose. Acute coronary syndrome (ACS), unstable angina pectoris (UAP), acute myocardial infarction (AMI) and sudden cardiac death, and other common pathophysiological process based intracoronary not The stable plaque rupture partners surface thrombosis is characterized. Inflammation in atherosclerosis (AS) has played a very important role throughout the aggregation of inflammatory cells to plaque rupture the entire process. Matrix metalloproteinases by degradation of the extracellular matrix (ECM), causing the thinning of the fibrous cap and apoptosis, leading to erosion and rupture of atherosclerotic plaque. Recently reported macrophage migration inhibitory factor (MIF) and matrix metalloproteinase -9 (MMP-9) is closely related to the formation of the atherosclerotic plaque, but the role of both the ACS has not been fully elucidated. The experiment by studying the UAP, AMI patients with the MIF, MMP-9 serum changes of characteristics, to observe the impact of its relationship with the number of coronary lesions and coronary stenosis and percutaneous coronary intervention the surgical (PCI), which explored MIF, MMP-9 ability as a predictor of the risk ACS patients. Select 130 patients with the diagnosis of coronary artery disease in patients with coronary heart disease and coronary angiography (CAG) confirmed 44 cases divided into SAP group, UAP group of 46 cases and 40 cases of AMI group. Another Select CAG results of 35 cases of normal for the normal control group. All patients were admitted to hospital the next morning fasting venous blood samples of 5 mL interventional treatment of patients, respectively, after 6h, 24h, 30d blood, using enzyme-linked immunosorbent assay (ELISA) to detect serum the MIF, MMP-9 levels . Each group were compared before and after PCI surgery, different number of coronary lesions of coronary stenosis between serum MIF, IL-6 levels, and patients with ACS MIF and MMP-9 between correlation analysis. Results 1. Groups serum MIF, MMP-9 levels: UAP group and AMI serum MIF, MMP-9 levels compared with the control group and SAP group was significantly higher (P lt; 0.05), but the the UAP group with the AMI group, SAP group Compared with the control group showed no significant sex (P gt; 0.05). Serum MIF, MMP-9 levels between different 2.ACS patients with coronary lesion counts: single-group support, double support group, three groups of serum the MIF, MMP-9 levels difference there was no significant sex (P gt; 0.05). 3.ACS patients with coronary stenosis between serum MIF, MMP-9 levels: mild stenosis group, moderate stenosis, severe stenosis serum MIF, MMP-9 levels were not significantly different sex (P gt; 0.05 ). Correlation between 4.ACS patients with MIF and MMP-9: ACS Serum MIF and MMP-9 levels were positively correlated (r = 0.78, P lt; 0.05). 5.PCI before and after surgery MIF, MMP-9 changes: the ACS patients after PCI 6h, 24h serum levels significantly higher than the preoperative differences were significant sex (P lt; 0.05 or 0.01), but postoperative 30d preoperative In comparison, did not change significantly (P gt; 0.05). Conclusion 1. Serum the MIF, MMP-9 levels and coronary plaque instability, regardless of the degree of coronary stenosis, and positive correlation between MIF and MMP-9. 2.PCI postoperative 6h, 24h serum MIF, MMP-9 levels were significantly higher than before surgery, but postoperative 30d with preoperative comparison, did not change significantly, suggesting that the MIF, MMP-9 involved in the early inflammatory response after PCI coronary .
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