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The topics for ulcerative colitis (UC), starting from the modern traditional Chinese medicine drug delivery systems angle, to the colon rather as a model drug, prescription astragalus polysaccharides, saponins made the stomach release unit, matrine, oxidation flavescens alkali made the colon-unit with dual release characteristics of the stomach, colon colon rather Compound release Dropping Pills. The topics discussed the compound drug delivery system design ideas, preparation methods, and evaluation techniques, common problems, the main contents are as follows: the drug properties of semi-finished products of traits, TLC identification, determination of project and related substances check inspection of semi-finished products of qualitative and quantitative methods to establish the quality standard of the semi-finished products. Matrine, oxymatrine and Dripping Pill shaped matrix mixed by a certain percentage, drip molding. A single factor, matrix types, matrix, and the proportion of drug, feed temperature, type of condensing agent, condensing temperature drops from the drip rate influencing factors were investigated. Select the matrix and the proportion of the drug, the temperature of the solid to liquid and drip rate on the dropping process on the basis of single factor has a greater impact factors as study factors, examine the level of its optimum parameters as to arrange orthogonal experiment finalized dropping pills molding process. Flavescens Dripping Pill Eudragit S100, Eudragit L100, EC as coating materials, the design was prepared by the pH-dependent, pH dependent - Delay bound two colon targeted formulations. Then the APS, the daily dosage of astrageloside basis with appropriate accessories mixed in proportion with the pan-system of law re-package the drugs flavescens coating Diwan clothing, the outer layer of the drug the clothing is stomach dissolved part. Preparations quality standards established astrageloside, matrine, oxymatrine identified by TLC, the use of the visible - UV spectrophotometry and high performance liquid chromatography content determination preparations to establish a Determination of preparation method. The in vitro release test, established preparations in vitro release determination method and speed of the stirring paddle dissolution medium pH value of the release of the performance of the two formulations, the results showed that the pH dependent - Delay positioning release The drug is better than the stability of the pH-dependent. Observed under pH-dependent - the Delay type coating Dripping Pill set the scanning electron microscope to study the drug release mechanism, experiments show that the the dropping pills release behavior consistent with the original design. At the same time, barium sulfate contrast pH dependent - Delay colon targeted drug delivery in vivo release performance were investigated, and the results show that the preparation in the normal human body has basically reached the colon-release effect.
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