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The Affections to 2AR-β-arrestin2-NF-κB p65/STAT6 Signal Transduction Pathway of Wumeiwan on Rats with Ulcerative Colitis

Author: LiangLi
Tutor: FanHeng
School: Huazhong University of Science and Technology
Course: Traditional Chinese Medicine
Keywords: Ulcerative colitis Rat model β2AR β-arrestin2 NF-κBP65 STAT6 Wu Mei Wan
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 83
Quote: 0
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Abstract


Objective ulcerative colitis in rats before and after treatment β2AR, β-arrestin2, NF-κBP65, STAT6 expression levels . Methods SD rats were randomly divided into four groups: normal group, model group , the United States Sarah triazine group and western medicine pills medicine ebony groups of eight . After the successful establishment of the model control group and model group were administered with saline 3ml , western medicine group with the beauty of Sarah hydrochloride 50mg/ml suspension 50mg/100g gavage, Medicines given 0.515g/ml ebony pill liquid 3ml gavage each group were administered continuously for 15 days, beginning on day 16 rats were killed after 24 hours of fasting . Spleen and colon tissue were used western blot method, immunohistochemistry and RT-PCR assay rat spleen and colon tissue β2AR, β-arrestin2, NF-κBP65 and STAT6 expression . Results in normal tissues β2AR, β-arrestin2 expression is increased in model group was significantly decreased both (P lt; 0.01), after treatment , ebony beauty Sarah pill group both triazine group was significantly increased (P lt; 0.01), the difference was not statistically significant (P gt; 0.05). The NF-κBP65 and STAT6 expression in normal tissues less in the model group was significantly increased (P lt; 0.01), after drug treatment in the pill group ebony beauty Sarah triazine group was significantly decreased (P lt; 0.01 ) , the difference was not statistically significant (P gt; 0.05). Conclusion ebony pill treatment of ulcerative colitis is one of the mechanisms by regulating β2AR-β-arrestin2-NF-κBp65/STAT6 signal transduction pathways to achieve

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