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A Series, Randomized, Single Blind Control Clinical Trial of Gatifloxation in Treatment of Acute Treatment of Bacteria Infection

Author: LiDaJiang
Tutor: LeiBingJun
School: Sichuan University
Course: Internal Medicine
Keywords: Gatifloxation Ciprofloxation Levofloxacin randomized controlled clinical trial Antibacteria activity
CLC: R515
Type: Master's thesis
Year: 2003
Downloads: 34
Quote: 1
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Abstract


Objective: To evaluate the clinical efficacy and safety of gatifloxation for treating acute bacteria infection; To investigate the antibacterial activity of gatifloxation against various fresh clinical isolates in vitro. Methods: A randomized, single blind controlled clinical design was used to accomplish the series clinical trials included 123 cases. The troop of gatifloxation injection with sodium chloride included 20 cases in gatifloxation group and 23 cases in ciprofloxation group; The troop of gatifloxation injection with glucose included 21 cases in gatifloxation group and 19 cases in levofloxacin group; The troop of gatifloxation pivoxil included 19 cases in gatifloxation group and 21 cases in ciprofloxation group. The antibacterial activity of clinical isolates were detected by scrips which contain gatifloxation(5ug/L), levofloxacin (5ug/L), ciprofloxation (5ug/L) , spafloxation(5ug/L) , cefotaxime(30ug/L) , penicillin(10U/L) respectively. The MICs of sixkinds of antibiotics were detected by 2-fold agar dilution method. Result: The common data of patients in the two groups of 3 troops were similiar. The clinical effective rates of gatifloxationand ciprofloxation in the 1st troop were 100% and 91.30%, bacteriological effective rates were 100% and 89.47%, bacteria eradicate rates were 100% and 100%, the rates of adverse reaction in two groups were 12.5% and 4.17%. The clinical effective rates of gatifloxation and levofloxacin in the 2nd troop were 95.23% and 89.47%, bacteriological effective rates were 94.74% and 87.50%, bacteria eradicate rates were 100% and 93.75%, the rates of adverse reaction in two groups were 4.76% and 0. The clinical effective rates of gatifloxation and ciprofloxation in the 3rd troop were 94.74% and 90.48%, bacteriological effective rates were 94.74% and 94.11%, bacteria eradicate rates were 94.74% and 100%, the rates of adverse reaction in two groups were 0 and 14.29%. One case in gatifloxation group of 1st troop stoped treatment in the course for the serious adverse reaction of center nerve systerm, and the other side effects were mild and not required treat. They could disappear by oneself without stopping administering drugs. The suspectivity rate of gatifloxation was 95.28% by K-B method and by MICs. Conclusion: Gatifloxation is a effective and safety antimicrobial agents for treating acute bacteria infections, which have powerful antibatria activity for various bacteria. It can be used to treat various infections due to many bacteria. However, it should be paid attention to the appeared bacterial resistance to gatifloxation.

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CLC: > Medicine, health > Internal Medicine > Infectious disease > Bacterial infection,bacterial infectious diseases
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