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Study on Electrochemical Sensors of Morphine

Author: LiuHaiXia
Tutor: GuoLiPing
School: Northeast Normal University
Course: Analytical Chemistry
Keywords: electropolymerization titration electrocatalysis molecularly imprinted polymer morphine ordered mesoporous carbon electrochemical sensor
CLC: TP212
Type: Master's thesis
Year: 2007
Downloads: 127
Quote: 0
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Abstract


In this work, two electrochemical sensors were prepared for the amperometric detection of morphine. Morphine was incorporated into a molecularly imprinted polymer （MIP）. MIP particles were prepared and characterized by UV-VIS-NIR spectroscopy and scanning electron microscope. Ordered mesoporous carbon （OMC） was synthesized and characterized by Nitrogen adsorption-desorption isotherm, powder XRD and FT-IR spectra. A stable suspension of ordered mesoporous carbon （OMC） was obtained by dispersing the OMC in a solution of Nafion. The suspension of OMC/Nafion was characterized by scanning electron microscope.Electropolymerization and titration methods were used to modify GC electrode with MIP particles. By coating the suspension onto the GC electrode, Nafion/OMC/GC electrode was prepared. The electrochemistry behaviors of the electrodes modified by MIP and OMC were studied, respectively.The oxidizing current of the MIP modified is measured in a KCl solution （pH 6.22 ） at 0.675V （vs. Ag/AgCl/ sat’d KCl） with morphine concentration varying in the 0.2-2 mM range. The sensitivity of 171.38μA/cm2mM （R=0.99） is obtained. The detection limit of 0.025mM at a signal-to-noise of 3 is achieved.Nafion-OMC/GC electrode exhibits strong and stable electrocatalytic response toward morphine, which shows a large determination range (4×10-9-4×10-4) mol L-1) and a remarkably low detection limit （1.5ng）.The results show that both two modified electrodes can electrocatalysis oxidation of morphine. These modified electrodes can be used as morphine sensor.

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