Dissertation > Excellent graduate degree dissertation topics show

Relative Bioavailability and Bioequivalent of Citalopram Tables in Healthy Volunteers

Author: ZhuGangZhi
Tutor: TangShengSong
School: Nanhua University
Course: Pharmacology
Keywords: Citalopram HPLC The relative bioavailability of Bioequivalence
CLC: R96
Type: Master's thesis
Year: 2007
Downloads: 113
Quote: 0
Read: Download Dissertation

Abstract


Objective To study the West citalopram tablets in healthy male volunteers in vivo bioavailability and bioequivalence . The method in accordance with the guiding principles of GCP , two - period crossover design , 18 healthy male subjects were randomly divided into two groups , were given a single oral dose of test preparation or reference preparations 2 x 20mg time point in the design of venous blood . HPLC method plasma concentration at different times after administration were measured by plasma concentration data for each of the main pharmacokinetic parameters main pharmacokinetic parameters of mean difference test , analysis of variance , with two one-sided t - test was used for the bioequivalence judgment . Citalopram tablets the test preparation and reference preparation main pharmacokinetic the parameters AUC 0 → 144 < / sub > , AUC 0 → ∞ < / sub > , T max < / sub >, C max were 1665.0 ± 318.3 ng · h / ml and 1670.6 ± 346.2 ng · h / ml , 1806.0 ± 371.6 ng · h / ml and 1822.9 ± 404.7 ng · h / ml , 4.6 ± 0.9 h and 4.6 ± 1.4 h, 34.3 ± 3.8 ng / ml and 35.2 ± 4.3 ng / ml . Reference preparation relative bioavailability of the test formulation of 100.5 ± 10.8 % . Statistical analysis indicated that the test formulation and reference no significant difference in the preparation of the main pharmacokinetic parameters between the two one-sided t-test results show that the test formulation and reference formulations are bioequivalent . Conclusion of the test preparation and reference preparation are bioequivalent .

Related Dissertations

  1. Study on the Pharmacokinetics of Xiaoaiping and Chlorogenic Acid in Rats and the Quality Standard of Xiaoaiping Preparations,R285
  2. Isolation Entophytes and Study on the Fermentation of Bacillus Subtilis tiD7 from Rehmannia,TQ461
  3. Studies on the Residues of Bromoxynil and Mesotrione in Maize and Soil,S481.8
  4. Cucumber Growth Promotion and Wilt Disease Suppression of Bacillus Subtilis SQR9 and Their Mechanisms,S436.421
  5. Production of Monoclonal Antibodies Against Thiabendazole and Development of Heterologos Elisa,S482.2
  6. The Yunnan ten kinds of pepper antioxidant and antibacterial activity of the research,S641.3
  7. Determination Method and Extraction Purification of Terpenoid Indole Alkaloids in Catharanthus Roseus,R284
  8. Study on Synthetic of BINOL, Amino Acid and Derivatives Molecularly Imprinted Polymers and Their Application in the Chiral Resolution,O631.3
  9. Extraction Condition of Paeoniflorin from Paeonia Lactiflora,R284.2
  10. Studies on the Detection Methods of the Tetracyclines Residues in Egg,S859.84
  11. Application IP-RP-HPLC method study of creatine phosphate in mice pharmacokinetics and metabolic disposition,R96
  12. Injection piperacillin sodium and tazobactam sodium content determination and compatible stability of visits,R927.2
  13. Acclimating, Screening and Degradation Characteristics of Pentachlorophenol-degrading Bacterium,R114
  14. The Structure Modification of Apigenin and Quercetin & 5-PBDMA Block the Potassium Channel, hERG,R285
  15. Candy orange and red orange fruit ripening changes of sugar and acid content,S666
  16. Study of the Best Method to Extract Sterols from the Mycelium of Hirsutella Sinensis by Orthogonal Design,S567.35
  17. New Prescription Aspirin with Sodium Bentonite Tablets and Its Protective Effect of Gastric Mucosa,R96
  18. The Effect of Maternal Pregestational Cus on the Serum CRH and COR, Brain Dopamine and 5-ht Metabolisms and Its Correlation with the Behavior of Offspring Rats,R714.2
  19. Drug on the chemical composition of dried ginger - galangal volatile oil and Salvia miltiorrhiza fingerprinting studies,R284
  20. Rosemary chemical composition and Quality Evaluation,R284
  21. Clinical Study and Experimental Study on Treatment of Tourette’s Syndrome (TS) by Qiangzhisan,R285

CLC: > Medicine, health > Pharmacy > Pharmacology
© 2012 www.DissertationTopic.Net  Mobile