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The Protection and Mechanism of Tea Pigments on Obesity-induced Insulin Resistance Rats

Author: SuChang
Tutor: LiaoHuiZhen
School: Fujian Medical
Course: Nutrition and Food Hygiene
Keywords: Tea Pigment Insulin Resistance Obesity Insulin sensitivity
CLC: R587.1
Type: Master's thesis
Year: 2007
Downloads: 84
Quote: 0
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Abstract


Objective: To observe the tea pigments on obesity induced insulin resistance rat model of intervention role, and to explore its possible mechanism. Method: 1. Establish obesity induced insulin resistance rat models of 80 male SD rats were randomly divided into two groups, the control group and the high-fat group. The control group of 10 and 70, the high-fat group. Respectively to the basic diet and high fat diet feeding. After 8 weeks of feeding, the tails of blood, determination of insulin and glucose levels. 20% increase in body weight compared with the control group, while insulin sensitivity index compared with the control group of low two standard deviations is the model rats. 2 tea pigments on insulin resistance in rats intervention research to select the model rats into intervention experiments, a total of 40. Randomly divided into 4 groups of 10. For the high-fat group, respectively, tea pigment, in the high-dose group, following to the high fat diet. Control group, following to the basic chow. Tea pigment, tea pigment in the high-dose group were given orally, at doses of 0.1, 0.2 and 0.4g/kg · BW control group and high-fat group were given distilled water orally, once daily for 8 weeks . The end of the experiment, the rats were sacrificed and blood samples were collected, insulin, leptin, and erythrocyte insulin receptor was measured by radioimmunoassay. Determination of blood glucose, triglycerides, cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and free fatty acids, and insulin sensitivity index. The rat kidney, liver, perirenal fat, epididymal adipose measured weight. Results: 1. Successfully established obesity induced insulin resistance rat models: Experiment 8 weeks of high-fat fed rats insulin levels compared with baseline diet rats (P lt; 0.05), insulin sensitivity index (P lt; 0.05) body weight of rats, higher triglycerides (P lt; 0.05). Intervention effect of tea pigments on obesity induced insulin resistance rat models: tea pigment, the high-dose group, body weight, body fat and compare the high-fat group (P lt; 0.05). High doses of tea pigments on insulin sensitivity index higher fat group (P lt; 0.05). Tea pigment in the high dose group of high insulin levels low-fat group (P lt; 0.05). 3 tea pigment possible mechanisms to improve insulin resistance: Tea Pigment group of middle and high dose can lower triglycerides and free fatty acid levels (with the group of high-fat ratio, P lt; 0.05), by the correct dyslipidemia, improve insulin resistance; high dose of tea pigments by decreased plasma leptin levels (with the high-fat group than in the P lt; 0.05), reduce the degree of insulin resistance; tea pigment high dose group can increase the number of high-affinity receptors (than the high-fat group, P lt; 0.05 ), improve insulin sensitivity. Conclusion: 1. Dyslipidemia, leptin resistance and insulin receptor decrease in the number of important mechanisms for obesity induced insulin resistance. Tea pigment can reduce obesity induced insulin resistance in obese rats and the degree of insulin resistance. 3 tea pigments reduce the possible mechanism of insulin resistance: reducing hypertriglyceridemia, lower free fatty acid, correct dyslipidemia; reduce the secretion of leptin to reduce the degree of insulin resistance; improve the surface of target cells by upregulating the number of high-affinity receptors insulin sensitivity.

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CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
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