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The purpose of China in recent years, alcohol-induced liver damage was also increased year by year, alcohol has become the second largest cause of liver damage following viral hepatitis after lead. IL-6 as the acute phase response factor involved in the liver tissue immune pathological response and inflammatory processes, resulting in damage to the liver tissue. In this study, patients with serum IL-6 levels at different stages of alcoholic liver disease (ALD) is compared with other biochemical indicators correlation analysis and understanding of IL-6 and ALD inflammatory activity of the liver tissue, the degree of liver damage significance of the relationship and the dynamic changes in the process of inflammation of the liver damage. The Shenyang City hospital for infectious diseases in June 2004 October 2005 for treatment of patients with alcoholic liver disease as the experimental group, 112 cases, including alcoholic fatty liver disease (AF) 38 patients with alcoholic hepatitis (AH) 36 cases of alcoholic liver the the hardening (AC) 38 cases, meet the the Liver Diseases Society of Chinese Medical Association to develop AF, AH, AC diagnostic criteria. The control group of 12 cases, exclusion of viral hepatitis and cirrhosis, diabetes, acute and chronic renal failure, coronary heart disease, acute pancreatitis and other diseases of healthy people. All accepted checks caught fasting venous blood, serum IL-6 was measured by sandwich ELISA method, according to the kit instructions. Automatic multifunctional microplate reader read out the OD values ??of all specimens, according to OD values ??of serum samples to detect the concentration corresponding to the standard curve. Clear control group and the test group of alcoholic fatty liver, alcoholic hepatitis, alcoholic cirrhosis, serum IL-6 in each group of data in line with the normal distribution, after the q test in comparison with the analysis of variance homogeneity of variance between the check after the group, and different periods of ALD IL-6 main indicators of liver function in ALT, AST, CHE, ALP, GGT, TBIL \Results IL-6 levels of various types of alcoholic liver disease compare AH and AC patients, serum IL-6 compared with the normal control group there are significant differences (P <0.01), and between AH and AC patients, AF and control group between serum IL-6 levels were not significantly different. AH patients with serum IL-6 was positively correlated with GGT AC phase serum IL-6 were negatively correlated with liver function in CHE, ALB. Conclusion 1, at different stages of alcoholic liver disease, serum interleukin-6 level differences, alcoholic hepatitis and alcoholic cirrhosis patients with serum IL-6 were significantly higher than normal, while alcoholic fatty liver serum IL-6 levels normal subjects did not change significantly. 2, serum interleukin-6 levels in various stages of alcoholic liver disease, liver damage certain alcoholic cirrhosis, IL-6 and prompts the liver's ability to synthesize the main liver function ALB, CHE related in alcohol hepatitis stage, IL-6, and GGT.
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