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The bone healing Capsules expression of osteoarthritis rabbit model of inflammatory factors in serum

Author: YangTao
Tutor: LiuYuanLu
School: Liaoning University of Traditional Chinese Medicine
Course: Orthopedics
Keywords: Osteoarthritis / TCM therapy The bone healing Capsules / pharmacodynamic IL-1 IL-8 TNF-a Articular cartilage Experimental study Animal
CLC: R274
Type: Master's thesis
Year: 2007
Downloads: 95
Quote: 0
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Abstract


Objective: To study bone healing Capsules expression of the serum of a rabbit model of osteoarthritis IL-1, IL-8 and TNF-alpha. Methods: Hulth modeling method OA model, modeling after intramuscular injection of penicillin week, prevention of infection, after 4 weeks of gavage, serum 6 weeks after the determination of IL-8, IL-1 and TNF-alpha level. Results: traditional Chinese medicine group model of serum IL-8, IL-1 and TNF-alpha was significantly lower than that of the model control group, the difference was significant (P <0.05). Conclusion: Chinese medicine bone healing Capsules significantly inhibited the serum of a rabbit model of osteoarthritis IL-1, IL-8 and TNF-alpha expression, a good therapeutic effect on osteoarthritis. Osteoarthritis as a common disease has been more attention. Early clinical manifestations are: mainly to stiff, tired, cold or minor trauma aggravated by physical change from one location to another location difficult to quickly relieve pain stiff little activity, the development of advanced joint pain worsened night's rest can wake up pain, pain is continuous until the joint deformity, swelling, functional activities impeded life can not take care of themselves. Modern medicine, osteoarthritis (osteoarthritis, OA) is the interaction between mechanical and biological factors, the articular cartilage cells, extracellular matrix synthesis and degradation of subchondral bone normal out of balance. However, OA is triggered by a variety of factors, including genetic, developmental, metabolic and traumatic factors, OA disease may involve the movable joint organization. The final performance of the OA disease: due to changes in cartilage cells and matrix morphology, biochemistry, molecular biology and bio-mechanics, leading to softening of the articular cartilage, fibrosis, ulcers, reduced hardening of the subchondral bone and ivory, bone superfluous and subchondral bone cysts. Foreign study of osteoarthritis (OA) of the various laboratory tests, from the perspective of molecular biology to examine. Conservative treatment with anti-inflammatory analgesic, an endless stream of new drugs, a sticky supplement and transparent acid therapy is more popular, this method is also widely used in the country; surgical treatment of osteoarthritis in a foreign country is widely used, arthroscopic , joint replacement technology has been very mature. Class in the country were also widely used, but there are side effects and higher cost of the drawbacks of unparalleled academic advantages and characteristics of Western medicine, Chinese medicine treatment methods, the experiment is more Capsules by observing the bone on bone and joint the effect of inflammation rabbit model of serum IL-1, IL-8 and TNF-alpha expression, to examine the Chinese medicine treatment of osteoarthritis, and from the perspective of molecular biology to explore its mechanism. 1 Materials and methods 1.1 Materials experimental animals :5-8-month-old rabbits 28, weight 1.4-2.5kg, as males by the Experimental Animal Center of Liaoning University of Traditional Chinese Medicine. 1.2 Experimental drugs (1) bone healing Capsules (main ingredients: Panax, blood, safflower, angelica, Chuanxiong, red peony root the frankincense (system), myrrh (system), rhubarb, teasel, Drynaria 16 Wujiapi taste, share Liaoning University of Traditional Chinese Medicine First Affiliated Clinical Hospital, Shaanxi Wang Fu delight Pharmaceutical Co., Ltd., Zhunzi

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CLC: > Medicine, health > Chinese Medicine > Journal of Orthopaedics
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