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The Molecular Mechanisms of Suppression of Colon Cancer Invasion and Metastasis by Selective Cyclooxygenase-2 Inhibitor Nimesulide

Author: XuFei
Tutor: WangGuoBin
School: Huazhong University of Science and Technology
Course: Department of General Surgery
Keywords: Cyclooxygenase-2 Colon cancer E - cadherin CD44v6 MMP-9 Invasion and metastasis
CLC: R735.3
Type: Master's thesis
Year: 2006
Downloads: 68
Quote: 0
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Abstract


Background and Purpose cyclooxygenase -2 (COX-2) and human colon cancer incidence closely related phenomenon , the presence of high expression in colon cancer . Non-steroidal anti-inflammatory drugs (NSAIDS) may reduce the incidence and risk of colorectal cancer and its mechanism is to inhibit the activity of cyclooxygenase -2 (COX-2) more than that . The research expression of COX - selective inhibitors ( inhibit COX-2 selective NSAIDS) role is mainly concentrated in the tumor proliferation and apoptosis of tumor for COX-2 selective inhibitor of tumor invasion and metastasis few studies of the effects of a . In this study, tumor invasion and metastasis from the start , high expression of COX-2 colon cancer cell line Caco-2 study , to study the impact of COX-2 selective inhibitor nimesulide on colon cancer invasion and metastasis-associated molecules explore the molecular mechanism of selective COX-2 inhibitors inhibit tumor invasion and metastasis . Cultured colon cancer cell line , Caco-2, with different concentrations of the selective COX-2 inhibitor nimesulide intervention , Western Blot analysis of E - cadherin expression changes detected by immunocytochemistry CD44v6 expression changes, changes in MMP-9 expression using real-time quantitative RT-PCR assay . Results nimesulide can enhance the E- cadherin expression in Caco-2 cells , and a dose - dependent manner ; application nimesulide can reduce the Caco-2 cells CD44v6 expression and a dose-dependent manner ; application Nepal nimesulide can reduce the Caco-2 cell expression of MMP -9 mRNA expression in a dose-dependent manner . Conclusions selective COX-2 inhibitor nimesulide can change colon cancer cell invasion and metastasis-related molecules ( E - cadherin , CD44v6, MMP-9) expression , thereby reducing the ability of colon carcinoma cell invasion and metastasis , initially clarified selective COX-2 inhibitors inhibit the molecular mechanisms of colon cancer invasion and metastasis .

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