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Experimental Study on Mechanism of Traditional Chinese Medicine Radix Salvia Miltiorrhizae Etc in Treatment of Acne Vulgaris

Author: LvQuanXing
Tutor: ZhangXiaoJie
School: Shandong University of Traditional Chinese Medicine
Course: Surgery of Chinese Medicine
Keywords: Acne Vulgaris Tanshinone IIA Baicalin Cryptotanshinone Berberine hydrochloride Matrine Mechanism
CLC: R275
Type: Master's thesis
Year: 2006
Downloads: 234
Quote: 4
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Selected on the basis of the review of the literature , Salvia , Scutellaria, Coptis , flavescens , to study the mechanism of their treatment of acne vulgaris . Salvia and other the effective monomer components of traditional Chinese medicine cryptotanshinone , tanshinone Ⅱ A, baicalin , berberine , matrine SZ95 human sebaceous gland cells cultured in vitro to observe the amount of lipid synthesis of SZ95 cells and intracellular lipid composition changes. Experimental study , we observed (a ) Tanshinone Ⅱ A Baicalin has direct inhibition of lipid synthesis in SZ95 cells . Matrine can promote lipid synthesis in SZ95 cells . (B) of the lipid composition found : ( 1 ) baicalin significantly inhibited tanshinone Ⅱ A on FFA synthesis ; ② berberine, tanshinone Ⅱ A significant inhibition of triglyceride synthesis ; ③ cryptotanshinone tanshinone Ⅱ A mild inhibition of cholesterol synthesis ; ④ matrine significantly inhibit the synthesis of wax esters / sterol esters . Clarify the mechanism of traditional Chinese medicine to treat acne part from the cell and molecular level .

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