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Rheological Study of an Acrylic Cement Itself and It’s Infiltration in Compacted Cancellous Bone

Author: XuDaQiang
Tutor: YangHuiLin
School: Suzhou University
Course: Orthopaedic Surgery
Keywords: Acrylic resin bone cement Compressed cancellous bone permeability Bone density Cancellous bone compression ratio Rheological behavior
CLC: R683
Type: Master's thesis
Year: 2007
Downloads: 74
Quote: 0
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Abstract


Osteoporosis is the most common metabolic bone disease, a sharp rise in its incidence increases with age. Osteoporosis is characterized by loss of bone mass or an increase in porosity and strength decrease of bone structure, stress is less than the day-to-day activities, leading to osteoporotic fractures. Osteoporotic vertebral compression fractures (OVCFs) is the most common, and usually cause back pain. Retrospective and prospective studies indicate that percutaneous vertebroplasty (PVP) and balloon dilatation kyphoplasty (PKP) in the treatment of symptomatic OVCFs significant clinical effect, can effectively relieve pain, improve quality of life. PVP treatment aims to strengthen the objectives of vertebral, intraoperative bone cement viscosity is relatively low, a higher injection pressure required; the PKP treatment objective is to strengthen the collapse of the vertebral body, as far as possible to resume its normal height, the intraoperative bone cement is relatively high viscosity required injection pressure is low. Acrylic resin bone cement in PVP and PKP widely used, however, little is known about the rheological behavior of bone cement in the vertebral body dispersion, related research is also limited. The purpose of this experiment is to study the rheological behavior of bone cement acrylic resin, to investigate the permeability of the specimens of bone mineral density and bone cement in a specific time, the specimen, the compression rate and the bone cement permeability (elimination of bone density). The purpose of the first part of the rheological behavior of acrylic resin bone cement from the theoretical and experimental study at room temperature (22 ℃) the rheological behavior of acrylic resin bone cement. Method to acrylic resin bone cement (together materials are, Tianjin) powder and liquid material, 2g powder in a 20ml syringe, 1 ml of liquid material is placed in a 1ml syringe. 1ml liquid material into 20ml syringe force shocks;, stopwatch timing at the moment of the injection material. After approximately 1 1/2 minutes after mixing, the bone cement injected through the vent 5ml syringe barrel within the experimental apparatus, the regulation of biological material test machine (MTS 858), so that the excess bone cement and air discharge. After 2 1/2 minutes after mixing, biological material test machine speed of 0.3mm / s promote the syringe piston in the cylinder, a constant rate of flow, pressure - displacement curve, so that the bone cement. The acrylic resin bone cement at low speed the flow time rheological behavior on two points: the first point, the injection pressure plateau bone cement powder mixed with the liquid material after 2 minutes 33 seconds to 2 minutes and 51 seconds ; second point, acrylic resin bone cement is thixotropic non-Newtonian fluid. Conclusions The results suggest that when the herald acrylic resin bone cement fluid flow must consider the flow of history. PVP and PKP operation, acrylic resin bone cement through the working channel to be injected into the target vertebral body, the cementless the rheological behavior very complex, the viscosity of the flow through the working channel distance change. Rheological behavior the theoretical research purpose of the second part of the bone cement compressed cancellous bone permeability theoretical study of bone cement penetration within the compressed cancellous bone. The method of preparation cylindrical cancellous bone specimens, so that the diameter and the experimental apparatus similar to the (first part of the experiment) in the syringe barrel the same inner diameter. After the compression of the specimen placed in the syringe bottom so that the bone cement to flow between the specimens bone microarchitecture at a constant speed. The experimental operating at room temperature (22 ℃). Results cancellous bone permeability and a mathematical function of time K (t) = vh S / [F (t)-f 0 ]. Conclusions bone cement in cancellous bone penetration process study, the the function theoretically established three levels of meaning: experimental design to eliminate the influence of bone cement can study the effect of compressed cancellous bone microstructure: experiment to eliminate compression loose micro-structure of the bone bone can study the effect of the nature of the bone cement; experimental control bone cement with compressed cancellous bone microstructure, bone cement can be studied under different flow rate of permeability variation. This part of the experiment to establish the function of the experimental device provides theoretical support for further study of the compression effect and evaluation of the micro-structure of cancellous bone bone cement rheological properties of PVP and PKP. The time of the research purposes of the provisions of the third part of the acrylic resin bone cement permeability experiments within the compressed cancellous bone specimens mineral density and bone cement in compression specimens of trabecular bone permeability. From frozen thoracic and lumbar vertebral system to take the cylindrical cancellous bone specimens (r = 6.06mm), to measure the bone mineral density. Screened 24 specimens were divided into two groups according to the distribution of the BMD. A group of 12 specimens, BMD dispersed range (0.1682 to .2919) g / cm 2 , for the third part of the experiment. Group A specimen compressed to 40% to the same experimental method as with the first part, the pressure - displacement curve of penetration of the bone cement in the compressed cancellous bone. According to the second part of the experiment function to calculate the average coefficient of permeability of the bone cement dispersion process within the stipulated time. Average permeability coefficient between bone mineral density and trabecular bone within the specified time, the specimens compression rate of 40% under the conditions moderate (R 2 = 0.5444, P <0.01), and between negative trend. Conclusion strengthened in percutaneous vertebroplasty (PVP and PKP) treatment of symptomatic OVCFs, the bone mineral density may be an assessment of the risk of cement leakage parameters. Under the conditions of a fourth part of the acrylic resin of the bone cement in the bone mineral density approximation, the compression ratio of the permeability of different specimens experimental research purposes in the exclusion BMD impact study predetermined time relationship between the rate and the permeability of the specimens compression. 12 specimens of the screened out by the method in the third part of another group (B group), the BMD values ??approximate range of (0.2523 to 0.2678) g / cm 2 . Group B specimens were randomly divided into two groups (group Ⅰ and group II), 6 specimens (group I) uncompressed, 10% of the the group Ⅱ specimens compression. The calculated average permeability coefficient of the diffusion process of the bone cement within the predetermined time and the third part of the same experimental methods. Results in the exclusion of the bone mineral density of the conditions under compression 10% of the specimens require time average permeability coefficient significantly less than no compression specimens average permeability coefficient, and the difference was statistically significant (P <0.001). The conclusion in PKP treatment of symptomatic OVCFs, surgery vertebral compression the cancellous bone cavity formed bone wall than PVP has potential advantages in reducing the risk of cement leakage.

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CLC: > Medicine, health > Surgery > Orthopaedic Surgery ( movement system diseases,orthopedic surgery ) > Fracture,bone damage
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