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The Association of TXNIP with Type 2 Diabetes and Insulin Resistance

Author: LuYuLian
Tutor: ChengXingBo
School: Suzhou University
Course: Internal Medicine
Keywords: thioredoxin-interacting protein type 2 diabetes insulin resistance obesity
CLC: R587.1
Type: Master's thesis
Year: 2011
Downloads: 50
Quote: 0
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Abstract


Objective :To explore the association of thioredoxin-interacting protein(TXNIP) with type 2 diabetes and insulin resistance.Methods: Fasting serum TXNIP concentrations was measured in 54 patients with type 2 diabetes mellitus(T2DM) and 30 normal controls by using enzyme-liked immunosorbent assay. Glycosylated hemoglobin A1c (HbA1c),body mass index (BMI),wais(tW),waist-to-hip ratio (WHR),totle cholesterol (TC),triglyceride (TG), high density lipoprotein (HDL-C),low density lipoprotein (LDL-C),insulin (INS) and fasting plasma glucose (FPG) were also measured in fasting status. According to BMI,patients with type 2 diabetes were divided into two groups, obese group(T2DM-OB) and normal weight group(T2DM-NW). Statistical analyses were performed with the use of SPSS13.0 software. We investigated the changes of serum TXNIP in different groups and its association with other clinic index.Results: (1) Serum TXNIP level was higher in T2DM group than normal control group(P<0.05). But there was no difference between T2DM-OB group and T2DM-NW group(P>0.05). (2) Pearson correlation analyses showed that TXNIP was positively correlated with FPG、HbA1c、HOMA-IR (P<0.01)(.3)Multiple linear regression analyses showed that HbAIC、HOMA-IR were independent determinants for serum TXNIP concentrations.Conclusion:TXNIP was strongly associated with type 2 diabetes and insulin resistance. It may play a very important role in the process of developing type 2 diabetes and insulin resistance.

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CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes
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