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Effects of Suifotanshinone Sodium on the Growth of SMMC-7721 Hepatoma Cells

Author: ZhangXiaoMing
Tutor: ZuoJingCheng；WeiWenXiang
School: Suzhou University
Course: Immunology
Keywords: Sulfotanshinone Sodium (STSI) SMMC-7721 hepatoma cells apoptosis VEGF
CLC: R735.7
Type: Master's thesis
Year: 2011
Downloads: 19
Quote: 0
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Abstract


Objective:To investigate the effect of suifotanshinone sodium (STSI) on the growth of SMMC-7721 heptoma cells.Methods:To observe cell morphology treated by different concentrations of STSI under the microscope on; Cell proliferation and adhesion were measured by MTT assay; Flow cytometry was applied to measure the effect of STSI on cell cycle and apoptosis of SMMC-7721. Gene expression was detected by RT-PCR.Results:With the increasing doses of STSI, the morphology of the hepatoma cells changed obviously; MTT assay showed that at 24h、48hand 72h after the treatment with STSI,the inhibition ratio demonstrated a dose-and-time-dependent relationship; Flow cytometry showed that the hepatoma cell was arrested in cell cycle with increased apoptosis. Expression of VEGF gene decreased obviously.Conclusion:STSI can obviously inhibit proliferation of SMMC-7721 in vitro,and can induce apoptosis of SMMC-7721 cells.

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