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Fish oil rich in EPA, DHA has a physiological role in the prevention and treatment of cardiovascular and cerebrovascular diseases , anti-inflammatory , inhibiting tumor , brain puzzle, prevent aging . Accordingly , EPA, DHA from fish oil extract high purity has become a hot topic in recent years . This study with the supercritical CO 2 continuous extraction of EPA and DHA from fish oil optimum conditions . In an inner diameter of 25mm, the the high 4.8m distillation column using supercritical CO 2 continuous extraction experiment, the rectification column has a total of six paragraph 6 of the feed inlet and the temperature gradient . To the bottom of EPA and DHA total content and the total recovery of experimental evaluation index , explore CO 2 than fish oil flow , the four parameters of the extraction pressure , temperature gradient , feed location of the extraction efficiency were investigated . On the basis of experiments in single factor , to the bottom of EPA and DHA of the total content and the total recovery of evaluation index, the fish oil flow rate fixed to the of ion exchange , the feed position is fixed in the second , the CO 2 than with fish oil flow , the three factors of the extraction pressure , temperature gradient orthogonal experiment . By orthogonal experiments come supercritical CO 2 < / sub> Continuous Extraction of fish oil EPA and DHA of optimal process conditions : fish oil flow 4ml/min, CO 2 flow 24l / min , extraction pressure 12.5MPa, temperature gradient 42 ~ 90 ℃, the second feed port . Under these conditions, the extraction efficiency of the bottom of EPA and DHA total content of 86.0% , and the bottom of EPA and DHA, the total recovery of 60.6% . Studies show that the supercritical CO 2 Continuous Extraction of fish oil EPA and DHA process is feasible , the extraction effect is relatively good .
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