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Detection method of iodine the ether Liu amine content in foods of animal origin and 2,6 - dimethyl-β- cyclodextrin synthesis process

Author: YangFen
Tutor: SongHongRui
School: Shenyang Pharmaceutical University
Course: Applied Chemistry
Keywords: High Performance Liquid Chromatography Dianmiliuan Content Bovine tissue Synthesis Process 2,6 - dimethyl -beta - cyclodextrin
CLC: TQ28
Type: Master's thesis
Year: 2008
Downloads: 71
Quote: 0
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Abstract


The ether to Liu amine content of iodine in the first part of the food of animal origin determination method iodine ether Liu amine (rafoxanide) is a halogenated Salicylanilide the class killing flukes drug phosphorylation by blocking Fasciola oxidation process , leaving the parasite paralysis and death , to achieve the purpose of insecticidal widely used in the treatment of liver fascioliasis of cattle and sheep , a significant effect. So far , the domestic its reported mostly concentrated in pharmacology, efficacy little its Determination reported in animal tissues . This paper established the the bovine tissue iodine the ether Liu amine content determination method available its pharmacokinetic study . Establish a HPLC method for determination of the cattle tissues iodine ether Liu amine content . Bovine tissue samples were extracted with acetonitrile , neutral alumina column purification using Kromasil C 18 ( 4.6 × 250 mm , 5 μm ) column with acetonitrile - water ( adjusted with phosphoric acid , pH 2.5 ) ( V : V = 83:17) as the mobile phase , UV detection wavelength 282nm, flow rate 1.5mL.min -1 , the column temperature was 30 ° C . Iodine ether Liu amine 0.05 to 4.0μg.mL of -1 < / sup > concentration range a good linear relationship (r = 0.9999), 0.01,0.1,0.4 μg.g -1 add three levels of low, medium , high , average recovery of muscle tissue samples were 78.3% , 85.8% , 95.1% ; liver tissue samples , the average recoveries were 73.3% , 83.9% , 91.9 % ; kidney tissue the sample average recoveries were 74.3% , 81.9% and 92.8% , respectively . Second portion of 2,6 - dimethyl -β-cyclodextrin synthesis process of β- cyclodextrin containing 7 D-glucose units cyclodextrin molecule thereof pores moderate , low production cost , but because of the β- cyclodextrin in C 2 < / sub >, C 3 hydroxy forming an intramolecular hydrogen bond , resulting in low water solubility , and limits their application in industry . Methylated cyclodextrin water-soluble , low toxicity , relatively low prices , wide range of applications , has become a research focus of domestic cyclodextrin modified . Therefore , we study its synthesis process . Β-cyclodextrin as a starting material , dimethyl sulfate as methylating reagent , N , N - bis dimethylformamide and dimethyl sulfoxide as a reaction solvent , in the alkaline conditions of the barium hydroxide octahydrate The following preparation of 2,6 - dimethyl -beta - cyclodextrin .

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