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In this experiment, normal saline, butorphanol, midazolam and both composite as Ma before administration induced with propofol research isoflurane anesthetic effect on the cat and cardio, EEG, ECG and plasma impact of changes in neurotransmitter noradrenaline and adrenaline. Were divided into four groups, the saline group (A), butorphanol group (B), midazolam group (C), and butorphanol - midazolam alprazolam composite group (D). In this experiment, Datex breathing, circulation monitor continuous monitoring of the cat respiratory system, circulatory system functions without injury. Cat plasma catecholamine neurotransmitters were measured by high performance liquid chromatography. The experimental results show that, before anesthesia, intravenous saline, butorphanol, midazolam and both composites, respectively, at an average pass into 1.93%, 1.39%, 1.44%, and 1.15% isoflurane, cat anesthesia best to reach the depth of surgical anesthesia level, sedative, analgesic effect indeed, compared with the control group, the latter three groups are different degrees of extension time of awakening. Respiratory monitoring results show that, although isoflurane and midazolam have a significant inhibitory effect on the respiratory function of the cat on the use of mechanical ventilation, but in this trial, by adjusting the isoflurane the inhaled concentration with tidal volume, during anesthesia to maintain unobstructed breathing animals, adequate oxygen supply, respiratory depression phenomenon did not occur among the groups. The circulatory system monitoring results show that, butorphanol, midazolam - butorphanol heart rate, blood pressure and body temperature as the extension of the duration of anesthesia show a downward trend, but a steady state heart rate, blood pressure drops to a certain extent, until the end of anesthesia monitoring did not continue to decline. Control group and midazolam group heart rate without significant changes, only to lower blood pressure. Groups oximetry significant effect, indicating that although various premedication some inhibition on the circulatory system, but each group physiological changes are within the tolerance range of the cat. EEG monitoring results show that, butorphanol, midazolam, or butorphanol promise - midazolam midazolam, isoflurane EEG pass into a sleep state by high-frequency low-amplitude alpha wave low frequency high amplitude δ wave transformation. Waking period, volatility was the change in the opposite direction. However, the phenomenon of waking time in the midazolam group and butorphanol promise - midazolam midazolam group. Plasma catecholamine test results show that, before anesthesia with butorphanol, midazolam and butorphanol - midazolam alprazolam significantly reduced plasma epinephrine and norepinephrine concentrations, that is, can effectively reduce the pain caused by stress reaction. The experimental results prove that the use of butorphanol, midazolam and butorphanol - midazolam alprazolam cat exclusive desflurane anesthesia premedication, smooth its induction of anesthesia, anesthetic effect is indeed, and can significantly reduce the different desflurane dosage, and also be able to significantly reduce intubation and extubation and anesthesia stress response cat. Said Ming Butuo brown Connaught, midazolam and butorphanol promise - midazolam alprazolam isoflurane anesthesia process the good narcotic analgesic effect, fully able to meet the cat clinical surgery needs.
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