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Biodegradable Microspheres for Parenteral Sustained Release of Lappaconitine

Author: XuHeLin
Tutor: ZhongHaiJun
School: Nanchang University
Course: Drug analysis
Keywords: Lappaconitine Microspheres PLGA Sustained-release Injection
CLC: R94
Type: Master's thesis
Year: 2011
Downloads: 34
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Abstract

The simple emulsion solvent evaporation method can be successfully wrapped lappaconitine instead hydrobromide PLGA microspheres . Various prescription process parameters such as emulsifier concentration ( PVA ) , stirring speed , DLGA concentration and drug / polymer mass ratio affect the nature of the microspheres prepared to study . The results show that the particle size of the microspheres are extremely distributed mainly by the PVA concentration , stirring speed and PLGA concentration control ; drug / polymer mass ratio and PVA concentration affect the encapsulation efficiency and burst release percentage of drug-loaded microspheres ; optimal formulation and process for 1.5% PVA, 50g / L PLGA, drug / polymer mass ratio of 1:5, stirring speed of 800 rpm ; optimal prescription of the preparation of microsphere size 19.3 ± 0.93μm, encapsulation efficiency was 70.77 ± 3.23 % drug loading 11.45 ± 0.47%. Further study on the basis of the optimal prescription drugs oil and water phases solubility distribution ratio on the encapsulation efficiency of the drug-loaded microspheres . The results show that good linear relationship exists between the encapsulation efficiency of drug-loaded microspheres with drug oil-water two-phase solubility distribution ratio . Optimal prescription microspheres obtained to adopt SEM , FT -IR , DSC and XRD further research . SEM studies have shown that the surface of the microspheres prepared smooth round particle size distribution is relatively uniform . DSC and FT-IR studies have shown that there is no significant interaction between the drug and the polymer . XRD studies show lappaconitine exists in molecular form or amorphous form of microspheres . Was prepared in order to study the mechanism of the in vitro release of the drug-loaded microspheres , respectively pH = 2 hydrochloric acid aqueous solution , distilled water washing treatment , the two groups of drug-loaded microspheres , the use of the dialysis method were studied in vitro release . The results showed that , in vitro release of acid water treatment group microspheres in line with a rate equation , and distilled water treated more in line with the zero-order rate equation .

Biodegradable Microspheres for Parenteral Sustained Release of Lappaconitine

Abstract

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