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Pressure Sensitive Adhesives and Polymer Nanoparticles for Transdermal Drug Delivery

Author: LiJun
Tutor: XuShen
School: Tianjin University
Course: Applied Chemistry
Keywords: Transdermal drug delivery system Hydrophilic pressure sensitive adhesive Polyurethane Polyvinyl pyrrolidone (PVP) Polyvinyl alcohol Polylactic acid Hydrogen bonds Amphiphilic copolymer nanoparticles
CLC: R94
Type: PhD thesis
Year: 2006
Downloads: 299
Quote: 1
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Abstract


The transdermal preparation is a more promising mode of administration, wherein as the drug reservoir both the pressure-sensitive adhesion effect of the pressure-sensitive effects of the preparations of the percutaneous administration have a great impact. The new type of pressure-sensitive adhesive for transdermal drug delivery system and novel transdermal delivery technology needs, developed three types of hydrophilic pressure sensitive adhesive and the two drugs nanocarrier materials and their properties have been studied. The reaction using a two-step Preparation of the hydrophilic nonionic polyurethane pressure-sensitive, i.e., by a mixture of a diisocyanate with a polyol prepolymer is generated, and then via the chain extender, the polyurethane pressure sensitive adhesive was prepared. Through the hydrophilic polyethylene glycol block introduced in the polyurethane main chain to give a pressure-sensitive hydrophilic. Prepared by the method of the physical blend of the PVP / PVA, PVP / polylactic acid hydrophilic pressure-sensitive adhesive of two types of Blends. Adhesive mechanical properties results show that the three types of pressure sensitive adhesive having good adhesion, permeability and water resistance, suitable for percutaneous administration system applications. TGA, DSC and DMA method detailed analysis of the state of presence of water in the hydrophilic substance composed of a blend of pressure-sensitive, results show that other components in the water and the pressure sensitive adhesive can occur strong hydrogen bonding interaction, system in 25% to 35% of water can enhance the strength of the pressure-sensitive network of hydrogen bonds and to ensure that the system a good flow deformability Blends exhibited pressure sensitive adhesive properties. To the PVP / PDLLA blends pressure-sensitive adhesive, for example, the study of the interactions between components and structural characteristics. Ultraviolet spectroscopy, infrared spectroscopy, differential scanning calorimetry analysis, tensile test shows that PVP and low relative molecular mass of polylactic acid strong hydrogen bonds and good compatibility. Salicylic acid as a drug model hydrophobic drug ibuprofen and hydrophilic drugs, the rat skin permeation experiments in vitro and in rats in vivo experiments, study of the pressure-sensitive adhesive transdermal drug as a drug reservoir and the adhesive layer permeability. The rats in vitro and in vivo experimental results show that the hydrophilic blends PSA has a self-promoting transparent role, is conducive to the proliferation of percutaneous drug than traditional rubber cream is a great increase in the quantity of drug penetration. This article also synthesized poly d, L-lactic acid-b-polyethylene glycol copolymer (PEDLLA), polycyanoacrylates acrylate-g-polyethylene glycol monomethyl ether copolymer (PEGECA) is two nano-carrier material, respectively, The molten dispersion method using solid-phase to load paclitaxel the PEDLLA nano-particles (PMT) was prepared, the nanoprecipitation prepared the load Tetrahydropalmatine PEGECA nanoparticles (PEGECAT). Nanoparticles as the test system, the proliferation of in vitro percutaneous penetration studies. Accepted solution using HPLC, scanning electron microscopy, infrared spectroscopy and nuclear magnetic resonance analysis using fluorescence electron microscopy of the organizational structure of the skin after percutaneous diffusion was observed, The results showed that both nanoparticles are diffusion of the drug wear to complete particle morphology load through the skin, nanoparticles percutaneous penetration may be passed skin appendages path and epidermal passing. The results of this study difficult to provide a new means of transdermal drug delivery by the transdermal delivery of drugs.

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