Dissertation > Excellent graduate degree dissertation topics show

Study on the Preparation of Biodegradable Microparticle and Its in Vitro Drug Release Kinetics

Author: LiJin
Tutor: DingFuXin
School: Tsinghua University
Course: Chemical Engineering and Technology
Keywords: Controlled release drug delivery system Microspheres Biodegradable materials Degradation Drug release mechanism
CLC: R94
Type: PhD thesis
Year: 2008
Downloads: 783
Quote: 2
Read: Download Dissertation

Abstract


Biodegradable drug-loaded microspheres in recent years, sustained and controlled release drug delivery systems, research focus, small size, diversity and versatility of the carrier material and applicable in a variety of modes of administration, on the release rate by control to significantly improve the safety and effectiveness of clinical medicine. In this paper, PLGA - poly ethylene glycol monomethyl ether copolymer (PLGA-mPEG) as the material for the development of drug-loaded microspheres loaded microspheres for drug release mechanism studies insufficient, from the microscopic structure of the microspheres and performance relationship, the analysis of the degradation of the material on the release behavior of the mechanism for the design and application of the guidance controlled release drug-loaded microspheres prescription. Small the hydrophobic molecule drugs methotrexate (MTX) as a model drug, examine the impact and the causes of the emulsion solvent evaporation method of process parameters on the nature of the drug-loaded microspheres. Through the orthogonal process optimization, higher encapsulation efficiency and sustained-release effect of MTX microspheres were prepared. The experiments show that the MTX and the material has a good compatibility. Certain drug loading process of release of MTX microspheres showed obvious three stages, including the initial burst release period, when demurrage and secondary burst release period. Microspheres degradation kinetics of the microspheres in the degradation process of the physical and chemical changes that occur with some regularity, and morphological changes differ for the different stages of drug release, degradation factors also control the release of the microspheres. The presence of the hydrophilic block is polyethylene glycol monomethyl ether (mPEG), accelerated the degradation rate of the material, to improve the flexibility of the material, thereby reducing the risk of the microspheres by external damage and chipping explanation drug, but also makes release demurrage greatly shortened. Microspheres degradation by its own nature and the release environment factors, these factors affect the degradation of the material on drug release indirect regulation. Paper studied the material composition of the four factors of drug loading, particle size as well as the release of environmental degradation kinetics mode of action of MTX microspheres, and then analyze each factor control law for a different release stage from which to expand the adjustment the release rate of the microspheres way to achieve controllable release rate of microspheres of important guiding significance. The mass transfer model describes the diffusion of the drug and the degradation of the material MTX microspheres release process, and the applicability of the model to research. Analyzed the relationship between the main factors affecting the degradation of the material and the drug diffusion coefficient, and the impact of the trend to make predictions. PLGA-mPEG and the compatibility of the hydrophilic drugs, were prepared microspheres of salbutamol sulphate (SBS), and lysozyme (LYS) microspheres. Serious burst release, the stagnation of the late release of the active macromolecules, adding additional agents to improve the preparation process for the encapsulation of hydrophilic drugs microspheres low, other methods to improve the quality of the microspheres.

Related Dissertations

  1. Study on the Degradation of Unsaturated Polyester Resin and Fiber Reinforced Polymer in Hot Compressed Water,TQ320.1
  2. Process Optimization and Degradation Kinetics for Microwave Vacuum Drying of Different Traditional Chinese Medicine Extract,TQ461
  3. Study on the Preparation of the Low Molecular Weight Fuciodan from Sargassum Henslowianum (C.Agardh) and Anti-tumor Activity,TS254.9
  4. Study on Activated Carbon Supported Cerium Catalytic Ozone Oxidation of Chloramphenicol,X703
  5. The Study of Preparation and Photocatalytic Activity of TiO2 by Electrospinning,O614.411
  6. Process and Mechanism of Eucalyptus Pulp Bleaching Catalysed by Cu2+/Co2+,TS745
  7. The Research on Sulfate Leaching Properties of Cation-exchange Resin Used in Power Plants,TQ425.23
  8. Study of Nitrobenzene Wastewater’s Treatment by Combination of Immobile Phanerochaete Chrysosporium and Activated Sludge,X703
  9. Study on the Breeding of High Efficient Detoxification Strains and Suggestion Parameters of Solid Fermentation on Cottonseed Meal,S816.6
  10. Detection of Exogenous Recombinan DNA of Transgenic Rice and Its Rice Product,S511
  11. Study on Detection of Transgenic Ingredients in Genetically Modified Cottonseed Meal and Its Degradation during Feed Processing,S816
  12. Purification of Human Respiratory Syncytial Virus Fusion Protein with Immunomagnetic Microsphere Technology,R373
  13. Isolation and Characterization of Carbendazim-Degrading Strains, Cloning and Expression of the mheI Gene,X172
  14. Isolation, Identification and Degradation Characteristics of a Benazolin-Ethyl Degrading Bacteria and Degradation Pathway,X172
  15. Isolation and Identification of Pyrene-Degrading Strain SE12 and Its Degrading Effect,X172
  16. The Interaction of Fluroxypyr with the Green Alga Chlamydonomas Reinhardtii,S482.4
  17. Isolation, Identification and Degrading Characteristic of a Cyhalofop-Butyl-Degrading Bacteria, and Cloning, Expression of a Cyhalofop-Butyl-Hydrolyzing Gene chbH,X172
  18. Preparation and Characteration of Composite Microspheres with Dual-, Triple- Responsive Properties,O631.3
  19. A Study on Environmental Behaviors of 2,4-D Butylate,TQ450.2
  20. Study on Oxidation Treatment of Phenol Contaminted Soil Using Potassium Ferrate,X53
  21. Study on the Three-stage Inoculant and Lignocellulose Gegradation in Dairy Manure Composting,S141.4

CLC: > Medicine, health > Pharmacy > Pharmacy
© 2012 www.DissertationTopic.Net  Mobile