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The Controlled Preparation of Mono Dispersed, High Saturation Magnetization Superparamagnetic Microspheres and Bio & Medical Application

Author: XuHong
Tutor: GuHongChen
School: Shanghai Jiaotong University
Course: Materials Science
Keywords: Superparamagnetic Coprecipitation The nano Fe3O4 particles , magnetic fluid Magnetic composite microspheres miniemulsion Magnetic classification Double miniemulsion monodisperse High saturation magnetization Inhibition Morphology control Surface functionalization Silicon oxide magnetic composite microspheres Surface structure Photonic crystal Nucleic acid extraction Immunochromatographic
CLC: TB383.1
Type: PhD thesis
Year: 2008
Downloads: 643
Quote: 3
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Abstract


Nanometer superparamagnetic microspheres in the separation and purification, immunoassay, diagnostic imaging, targeted drug delivery and treatment areas to be widely used. The big difference, both on the surface of magnetic microspheres and micro-structure, physical and chemical properties as well as microsphere particle size and distribution requirements for different biomedical applications. Superparamagnetic composite microspheres preparation technology is moving how to prepare a smaller particle size (nano-scale), and more uniform (monodisperse), higher content of magnetic material (high saturation magnetization), surface microstructure according to application requirements, the direction of the design and regulation development. Of this thesis is the response to these trends, innovative preparation methods, and through its in-depth study of the mechanism of nano-scale functional composite microspheres of uniform size, the higher performance of magnetic material content in a magnetic controllable preparation, and Preliminary its applied research. This thesis prepared monodisperse, high saturation magnetization polymer magnetic microspheres and high saturation magnetization silica magnetic microspheres used in nucleic acid purification immunochromatographic detection research, and the above two types of microspheres. The main findings are as follows: (1) by the analysis of the problems of traditional miniemulsion prepared magnetic composite microspheres, step miniemulsion method the joint magnetic grading methods to achieve a high saturation magnetization of the magnetic microspheres Controllable Preparation the magnetic beads average Fe3O4 content of more than 73wt% precision magnetic field sorting, magnetic composite microspheres array of monodisperse particle size can be obtained. (2) the compound based on miniemulsion droplets into nuclear emulsion polymerization method (dual the miniemulsion Act), monodisperse, controllable preparation of high saturation magnetization of the magnetic microspheres. The proposed critical control steps of the method is a composite prepared by miniemulsion droplets containing nano-Fe3O4 particles / octane \Through research on the mechanism of double miniemulsion method, explain the important factors to affect the performance of the magnetic microspheres and the microscopic structure and found Fe3 pair of polymerization inhibitor in the polymerization process. In addition, the the magnetic thin milk octane crosslinking comonomer DVB influence of the magnetic composite microspheres morphology, resulting microspheres appear very obvious asymmetric morphology when the magnetic the fine milk octane content more, with the significant increase in the amount of DVB microspheres MICROSEGREGATION structure is gradually improving. (3) in clear double fine milk preparation mechanism on the basis of, the core-shell structure of magnetic composite microspheres for nuclear, using acrylic comonomer, the preparation of the surface magnetic composite microspheres with carboxyl functional groups, carboxyl group content of from 0.27 mmol / g ~ 0.5mmol / g. (4) by to analyze heterogeneous nucleation and growth of silica magnetic microspheres morphology were studied proposed nuclear aggregates of magnetic particles and polymer magnetic microspheres, combined with improved sol - gel method, controllable preparation high saturation magnetization, monodispersed multicomponent composite silicon oxide magnetic microspheres. To Fe3O4/PS polymer magnetic microspheres, for example, the preparation obtained in the silicon oxide magnetic microspheres 2nm thickness of the silicon oxide shell, microspheres Nanoparticle Fe3O4 content of 70wt%. And regulation of the silicon oxide surface structure through the study and improvement of the sol - gel reaction conditions. (5) external magnetic field, the magnetic microspheres Fe3O4/PS polymer to the core can be prepared to obtain a stable silicon oxide magnetic chain structure, the length of the chain structure can be adjusted by the magnetic field strength; in the modulation of the magnetic field effect to obtain The magnetic microspheres can be formed superparamagnetic colloidal photonic crystals. (6) Preparation of this thesis a silicon oxide magnetic microspheres as a carrier to study the relationship of the microscopic structure of the surface of the silicon oxide with the nucleic acid extraction, showed that the synthesized silicon oxide microspheres can be effectively applied to the extraction of nucleic acids; functionalized by surface polymerization was magnetic microspheres as a model molecule to be seized for the signal marker hCG, microspheres can be effectively applied to the quantitative magnetic immunochromatographic detection system.

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