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Effects of Body-Weight Supoport Treadmill Training and Electroacupuncture on the Expressions of Nogo-A and Motor Function in Rats with Spinal Cord Injury

Author: ZuoRenGuo
Tutor: XingYanLi
School: Heilongjiang University of Traditional Chinese Medicine
Course: Rehabilitation Medicine and Physical Therapy
Keywords: Spinal cord injury Weight support treadmill training Nogo-A BBB score
CLC: R651.2
Type: Master's thesis
Year: 2011
Downloads: 21
Quote: 1
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Abstract


Objective: To establish an animal model of medullary cord injury . The observed weight support treadmill training combined with electrical hindlimb functional recovery for spinal cord injury in rats and the impact of the injury site Nogo-A . Methods: 85 Clean -level six -week-old healthy adult Wistar rats weighing 180 - 220g , all female . Randomly divided into five groups , blank group 5 , sham group , the control group, electro-acupuncture group , weight loss walk training combined with electro-acupuncture group ( needle Kang group ) , each group of 15 spinal cord cord injury model was successfully manufactured three days start EA group and needle Kang group were treated around the appropriate treatment . 3rd , one week , two weeks , three weeks , four weeks , the rats BBB rated . And in the other four groups of rats in the control group were randomly selected two rat to do paraffin sections of whichever injury District spinal cord tissue , by immunohistochemical methods combined with image analysis was used to observe Nogo-A expression changes . Results : spinal cord from full paralysis of both lower limbs off injury in rats , proved successful modeling spinal cord injury model . Nogo-A small amount of expression seen in normal adult rat spinal cord , Nogo-A expression in the spinal cord after spinal cord injury , spinal cord injury was significantly increased after 3d , 7d expression peaked after gradually reduced . The same time points the BBB rated needle Kang group was better than the EA group and both better than the control group ( p lt; 0.05 ) . - Nogo-A content comparison point in time , the needle Kang group was superior to the EA group and both better than the control group ( p lt; 0.05 ) . Weight support treadmill training combined with EA and EA alone can contribute to the recovery of hindlimb function in spinal cord injury , needles Kang group better than the EA group 2 weight support treadmill training combined with EA and EA alone conclusions : 1 . can affect the spinal cord transection injury in rats damage zone Nogo-A expression , needle Kang group was better than the EA group . Nogo-A when prompted to some extent inhibited the repair of spinal cord injury , but the exact mechanism needs further study .

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CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Spinal cord
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