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Efficacy of Guishao Liujunzi Decoction Combined with Adefovir of Treatment for Liver Cirrhosis of Chronic Hepatitic B

Author: ChenLiPing
Tutor: ShaoMing
School: Nanjing University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Integrative Medicine To Guishao Liujunzi soup Adefovir dipivoxil Cirrhosis Efficacy
CLC: R575.2
Type: Master's thesis
Year: 2011
Downloads: 52
Quote: 0
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The topics to Six Gentlemen Decoction Combined with adefovir dipivoxil treatment of liver cirrhosis Guishao start from biochemistry, virology, cirrhosis of the liver, such as a number of indicators and symptoms and signs in Chinese medicine, combined with adefovir the Guishao Liujunzi soup dipivoxil for the treatment of hepatitis B cirrhosis efficacy observation to explore the role of Traditional Chinese Medicine combined antiviral effective treatment means to provide new ideas for Integrative antiviral therapy for hepatitis B cirrhosis. Jiangsu Provincial Hospital of Traditional Chinese Medicine in September 2009 - March 2011 inpatients and outpatients in 40 patients with cirrhosis were randomly divided into two groups, namely, cases and naturalization of adefovir dipivoxil group (control group) Shao Liujunzi soup combined with adefovir dipivoxil group (treatment group) and 20 cases, the duration of treatment was 12 months. Were observed before and after treatment in patients with cirrhosis of the liver in patients with three clinical indicators (ascites, neuropsychiatric symptoms and nutritional status) and 2 Determination of liver function parameters (serum bilirubin and albumin), the degree of prolonged prothrombin time. Divided into A, B, C three different according to the degree of liver dysfunction, respectively detected, 0,1,6,12 months in treatment phase. According to the differences in scores between self-control and group to determine efficacy. TCM symptoms and signs in the two groups of symptoms 0, 1 month and 3, 6, and 12 months after treatment, the treatment group than the control group, the control group was statistically significant (p lt; 0.01). 3, 6, and 12 months after the treatment of the two groups of AST, ALT, A, GGT, TB treatment 0 improved significantly (p lt; 0.01). Two sets of AST, ALT, A, GGT, TB treatment between the groups 3, 6 and 12 months compared to treatment 0 control results were statistically significant (p lt; 0.05), to be effective in the treatment group and the control group improve liver function, but the treatment group vs. control group remain statistically significant. PT 0, 6, 12 menstrual statistical treatment group after treatment group comparison was not statistically significant (p gt; 0.05). Child improved liver function in patients graded integral Pugh integral Statistical analysis were as follows: the former various symptoms of treatment of 0.6 months and 12 months were significantly different (p lt; 0.01); latter The symptoms treatment 0 and 6 and 12 months were significantly different (p lt; 0.01); two after treatment between the two groups were statistically significant (p lt; 0.01). HBV-DNA at 0, 6, 12 menstrual statistical processing, treatment difference obviously 0 and 6 and 12 months, with a statistically significant (p lt; 0.01); treatment groups after contrast no statistically significant (p gt; 0.05). 0 months and 12 months, blood count, renal function indicators treatment in both groups were statistically platelets than before treatment was significantly higher (p lt; 0.01), compare other indicators before and after treatment, there was no significant difference (p gt; 0.05). Compare two groups of renal function after 12 months of treatment, there was no significant difference (p gt; 0.05). Renal function between the two groups, the number of abnormal cases compared by chi-square test, each indicator compared between the two groups were not statistically different (p gt; 0.05). During treatment, normalized of Shao Liujunzi soup combined with adefovir dipivoxil can play the advantages of Traditional Chinese Medicine, and effectively improve the patient's symptoms. The United Guishao Liujunzi soup treatment, can improve the the adefovir dipivoxil response rate of hepatitis B virus (including virologic response, serological response, biochemical response), this important antiviral treatment and prognosis. Clinical observation found Guishao the Six Gentlemen Decoction combined with adefovir dipivoxil can improve liver function and histological changes, slow progress to decompensated cirrhosis, reduce the incidence of hepatocellular carcinoma, hepatitis B cirrhosis decompensation can be sustained suppression of HBV, improve liver function and slow disease progression, reduce the incidence of complications, improve survival and reduce the incidence of liver cancer. Can improve the liver function of patients with cirrhosis grade points, this antiviral treatment and prognosis of liver cirrhosis is of great significance. Through clinical observation, the treatment group in many ways superior to the control group.

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CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Liver and gall bladder disease > Cirrhosis
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