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Umbilical Cord Blood Stem Cell Transplantation for Treatment of Ulcerative Colitis

Author: LiBaoHuan
Tutor: XuChangQing
School: Shandong University
Course: Internal Medicine
Keywords: Umbilical cord blood stem cell Ulcerative colitis Stem cell transplantation
CLC: R574.62
Type: Master's thesis
Year: 2011
Downloads: 30
Quote: 0
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Abstract


Objective:Ulcerative colitis is a chronic nonspecific intestinal inflammatory disease, while at present the etiology and pathogenesis are not entirely clear. The conventional drugs are 5-aminosalicylic acid, glucocorticoid and immunosuppressant, but the safety and efficacy of drugs will decline after a long-term use. The disease will break out repeatedly. Advances in our understanding of the cell populations involved in the pathogenetic processes and recent findings on the regenerative, trophic and immunoregulatory potential of stem cells open new paths in UC therapy. This study is to analyze the treatment effect of the umbilical cord blood stem cell transplantation on the patients with ulcerative colitis.Methods:The cases of UC were collected from 2009 to 2010.60 patients with moderate to severe ulcerative colitis were all treated with conventional durgs, and 29 of them were given stem cell therapy based on the traditional treatment. The umbilical cord blood stem cells, which were separated from 70 to 100ml umbilical cord blood from healthy women, were transplanted into the intestinal tract through inferior mesenteric artery. And then, we should record the changes of clinical, endoscopic and pathological characteristics carefully, and do statistical analysis according to the disease activity index score.Results:One week after the transplantation, the clinical symptoms and signs were much improved. After four weeks, the clinical symptoms and signs have almost disappeared and never relapse in 24 weeks. Colonoscopy examination displayed that the intestinal inflammation disappeared and the blood vessels texture became clear. Inflammatory polyps reduced. There are two patients who were presented with fever. No other adverse reaction occurred in 24 weeks. The patients from control group were also becoming better, but most of them relapsed in 24 weeks. According to statistical analysis, we can know that stem cell therapy is more effective than traditional treatments.Conclusions:Umbilical cord blood stem cell transplantation in the treatment of ulcerative colitis can significantly reduce inflammation, repair the injured intestinal mucosa and reduce the complications. It will greatly improve the patients’life quality and the long-term outcome is better than traditional treatments. Therefore, the stem cell therapy is of high value in use.

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CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Bowel disease > Colorectal disease > Colonic disease
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