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Objective : To observe the rhubarb ( Rheum water extract of rhubarb decoction ) and Coptis ( Coptis extract , Coptis decoction ) on the heat of rat body temperature, chills and fever trends, locomotor activity , metabolism, energy metabolism, thyroid axis function , cytokine activity , analyze trends in its role , characteristics and laws , exploring cold medicine treatment of febrile disease, efficacy mechanism for better clinical treatment to provide a reference index . Methods : To observe the heat of rats given temperature after cold medicine , cold and heat trends, such as changes in locomotor activity ; using chemical colorimetric spectrophotometer assay glycogen , triglycerides, pyruvate , ATP enzyme activity , amber acid dehydrogenase activity ; using automatic microplate assay of plasma T 3 , T 4 , TSH, TRH, IL-1 β , IL-6, IL-8, TNF-α content . Results: Compared with model group , rhubarb , berberine could significantly reduce the heat of body temperature of rats ; able to reduce the number of activities ; able to increase glycogen and triglyceride levels , inhibit the formation of pyruvate ; could reduce ATP enzyme succinate dehydrogenase activity ; inhibited hypothalamic - pituitary - thyroid axis function ; were on cytokine activity to some extent. Conclusion: cold heat of herbs on rat body temperature, locomotor activity , metabolism, energy metabolism, thyroid axis function , cytokine activity have a certain extent , this is the future of cold Chinese herbal medicine research and clinical applications provide valuable reference data .
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