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Tanshinone ⅡA on Myocardial Ischemia-reperfusion Injury in Rats and Its Mechanism of Clinical Research

Author: ZhangSongFei
Tutor: PanTao
School: Nanjing University of Traditional Chinese Medicine
Course: Traditional Chinese Medicine
Keywords: Tan muscle sodium phosphate myocardial ischemia reperfusion injury (MIRI) interleukin-6 (IL-6) interleukin-10 (IL-10) tumor necrosis factor-α(TNF-α) nitric oxide (NO) superoxide dismutase (SOD) malondialdehyde (MDA)
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 82
Quote: 1
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Abstract


Purpose:1. Clearly tanshinone IIA injection on myocardial ischemia-reperfusion injury.2. Of inflammatory cytokines TNF-a, IL-6, IL-10, NO, SOD, MDA and Myocardial ischemia-reperfusion injury associated injection of tanshinone IIA on it.3. Clarify tanshinone IIA injection on myocardial ischemia-reperfusion injury mechanism is inhibition of inflammation.4. Clearly tanshinone IIA injection in myocardial ischemia-reperfusion injury to scavenge oxygen free radicals.Method:Collection 2010.5-12-month period due to "acute chest pain" patients hospitalized for treatment, the condition of patients in the informed consent of patients underwent SCAG, and preoperative TNF-a, IL-6, IL-10, NO, SOD, MDA and other blood biochemistry. Will need to line patients undergoing PCI were divided into control group and treatment group, postoperative blood-related biochemistry. By preoperative and postoperative control study of tanshinone IIA on myocardial ischemia-reperfusion injury clinical therapeutic value. Analysis of TNF-a, IL-6, IL-10, NO, SOD, MDA and myocardial ischemia-reperfusion injury and the corresponding correlation mechanism.Results:1, into the group of patients before and after PCI, serum TNF-a, IL-6, IL-10, NO, SOD, MDA comparison, after TNF-a, IL-6, MDA level higher than that before operation, the difference statistically significant (P<0.05); after IL-10, NO, SOD levels decreased more after surgery, the difference was statistically significant (P<0.05).2, treatment group compared with the conventional treatment group, treatment group postoperative serum TNF-a, IL-6, MDA levels lower than the conventional treatment group, the difference was statistically significant (P<0.05); postoperative serum treatment group IL-10, NO, SOD levels higher than the conventional treatment group, the difference was statistically significant (P<0.05).3, the western medicine group and the conventional treatment group, the western medicine group were serum TNF-a, IL-6, MDA levels lower than the conventional treatment group, the difference was statistically significant (P<0.05); Western treatment group, postoperative serum IL-10, NO, SOD levels higher than the conventional treatment group, the difference was statistically significant (P<0.05).4, Chinese medicine and western medicine treatment group compared with postoperative serum TNF-α, IL-6, IL-10, NO, SOD, MDA levels were not statistically significant (P> 0.05).Conclusion:1, Tan and sodium phosphate can relieve muscle ischemia reperfusion injury severity.2, myocardial ischemia and reperfusion injury induced serum TNF-α, IL-6 and IL-10 increases reduced muscle sodium tanshinone and phosphoric acid can reduce TNF-α, IL-6 release, and promote the release of IL-10, reduce reperfusion injury.3, myocardial ischemia caused by elevated serum MDA and NO, SOD decreased muscle sodium tanshinone and phosphoric acid can increase NO, SOD levels and reduce the MDA production, reduce reperfusion injury.

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