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A Study of the Efficacy, Mechanism and Safety of Showshow on Simple Obesity

Author: FuChen
Tutor: OuYangWuQing
School: Northwest University of Science and Technology
Course: Physiology
Keywords: Thin tea Obesity Efficacy FAS Security
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 55
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Abstract


Objective: To study the thin tea on obesity efficacy, mechanism of action and safety, provide a scientific basis for clinical application. Methods: The establishment of normal control group, model building obese mice, divided into four groups after the success of the test, the model control group with distilled water, the positive control group was fed with sibutramine, high and low dose drug group to thin tea gavage. Lipschitz exponent detection and analysis of each group, body mass growth, fat factor and lipid levels and other indicators of changes, record the group of anti-fatigue test, the swimming time and energy performance; RT-PCR method for detection of mouse liver fatty acid synthase ( FAS) gene expression, and through the evaluation of acute oral toxicity test the safety of thin tea. Results: 1. Modeling: high-fat diet in mice fed the basal diet body mass higher than 20%. Successful model. 2 slimming effect: administration, drug group mice physique than 7% below the model control group, the difference was significant (P lt; 0.01), little difference with the positive control group (P gt; 0.05); body mass growth was 23.71 ± 1.78%, the lowest in each group and the difference was significant (P lt; 0.05); Lee index was 3.355 ± 0.083, significantly lower than the model group (P lt; 0.05), the difference between the positive control group not significant (P gt; 0.05); fat mass than the model control group 47% of the difference was significant (P lt; 0.05); fat coefficient of 3.50 ± 1.90%, significantly lower than the model control group and positive control group (P lt ; 0.05); abdominal fat deposition less than the model group. HE staining showed that the drug group mesenteric fat cells in the abdomen of mice was significantly less than the control group. 3 spleen effects: after administration of the drug group mice swimming time was 15.02 ± 2.49 min, 1-fold higher than the model in the control group (P lt; 0.05), 2.6 times higher than the positive control group leader (P lt; 0.01). 4 lowering effect: serum levels after administration of drugs TG, TCH, HDL-C concentration was 0.7378 ± 0.1293 mmol / L, 3.2584 ± 0.5060 mmol / L, 2.5447 ± 0.4425 mmol / L, compared with the model group were reduced by 28.8%, 13.3%, 14.7%, significantly different (P lt; 0.05). 5. Often effective lipid-lowering effects: lipid levels in two groups of mice when measured in the basic difference was not significant (P gt; 0.05). After treatment, the drug group and TCH serum TG concentrations were 1.014 ± 0.408 mmol / L and 3.173 ± 0.225 mmol / L, 40% lower than the control group and 29% (P lt; 0.05), HDL-C concentration was 2.014 ± 0.278 mmol / L than the control group 29% (P lt; 0.05). 6. FAS expression: RT-PCR results showed that the drug group FAS mRNA expression in mouse liver than the model control group, lower than the normal control group. 7 Security: Acute oral toxicity test in mice without poisoning or death phenomena; maximum dose trial was the largest dose 180 g · kg -1 · d -1 , discounted crude drug was 868.8 g · kg -1 · d -1 ; HE staining showed that the drug group murine small intestine with no significant difference between the control group. Conclusion: The test chamber homemade compound thin tea followed the theories of Chinese medicine, can speed up the body's energy metabolism, reduce fat accumulation in mice with lipid-lowering diet, and the role of the spleen. Thin tea does not affect appetite, does not cause diarrhea, toxicity, harmless to the body, in line with international principles of weight loss is a reasonable combination drug prescriptions, with further research value.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
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