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Effects of Organophosphorus and Pyrethroid Pesticides on Estrogen

Author: ChenHaiYan
Tutor: WangXinRu;XiaoJiGao
School: Nanjing Medical University
Course: Pharmacology
Keywords: Organophosphorus pesticides Pyrethrin pesticides Proposed estrogenic activity Estrogen receptor competitive binding assay Cell proliferation assay pS2 mRNA expression experiments
CLC: R96
Type: PhD thesis
Year: 2002
Downloads: 259
Quote: 0
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Abstract


The first part of organophosphate and pyrethroid pesticides intended purpose of estrogenic activity : study of five kinds of organic phosphorus [ of phoxim and ( Pho ) , malathion ( Mal ) , dimethoate (Dim ) , monocrotophos (Mon) isocarbophos (Opt ) , and four kinds of pyrethroid pesticide fenvalerate (Fen), deltamethrin (Del), cypermethrin ( Cyp ) , permethrin (Per)] intends to estrogen activity. Method: 1 , rat uterine estrogen receptor (ER) competitive binding assays ; 2 , human breast cancer MCF-7 and MDA - MA- 435S cell proliferation assay ; 3 , human breast cancer MCF-7 cells pS2mRNA expression test . Results: 1,5 organophosphorus pesticides in vitro are not combined with rat uterine ER ; 4 kinds of proposed text Nanjing medical PhD thesis pyrethrin pesticides in vitro with 'H . A competitive ER, its ability to bind Fen Cyp > Per Del Fen and Cyp suppression cattle IJ'H -E . Binding IC and ER . . The stars separate 0.479mmol / L and 0 * 62 mmol / L . Organophosphorus pesticides can not induce proliferation of MCF Diao cells ; pyrethroid pesticides can cause proliferation of MCF7 cells to stimulate the proliferation ability of Per > Fen > Del > Cyp which Cyp , Del and Per the bow from the proliferative effect estrogen antagonist ICI 82.780 completely blocked 6 FeN caused Lan cell proliferation can not be completely blocked . Addition hn sterile promote MDA-MA-4355 Kyu cellular proliferation , the rest keep pyrethrin pesticide MD A-MA435S cells no effect on proliferation . The Fen , Cyp and shellfish , r Desk induced expression of pSZ mMA , 6Del the role . Conclusion: l , intended to de-worming esters pesticides by activating ER show that it is intended to estrogenic activity ; 2 the Fen induction of MCFj of cell proliferation is not entirely caused by ER activation ; 2 , organophosphorus pesticides not have intended to estrogenic activity .

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