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The Study of Qilian Shupi Granule in Treating Precancerous Lesions of Chronic Atrophic Gastritis in Clinic and Inhibiting Factors

Author: CaoZhiQun
Tutor: ZuoJiWu
School: Shandong University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Qi Lin Shu ruffian particles Precancerous lesions of chronic atrophic gastritis Angiogenesis Chinese medicine treatment / Jianpiyishenfang Qi circulation Relieves congestion detoxification
CLC: R259.7
Type: PhD thesis
Year: 2002
Downloads: 351
Quote: 4
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Objective: This study aimed to explore in depth the use of the theory of traditional Chinese medicine, from clinical and experimental chronic atrophic gastritis and precancerous lesions of the disease and its law governing prescription to seek the pharmacodynamic mechanism of Chinese medicine to treat the disease. : According to the clinical syndrome, chronic atrophic gastritis pain lesions of the spleen and stomach deficiency, blood stasis intrinsic toxicity, the poor will be renal intends spleen and kidney, qi circulation, open end detoxify the rule of law. Accordingly sent Prescription drug made the Qi Lin Shu the ruffian particles (qLSP), with modern process. The clinical treatment of chronic atrophic gastritis and precancerous lesions in 61 cases, and 40 cases Weifuchun, 36 cases Weimeisu 1 control group, clinical and therapeutic comparison. While observing the H pylori clearance rate, blood cAMP, SOD, LPO, TXB 2 , 6-K-PGF 1alpha QLSP group and control group before and after treatment. Experimental study made in Wistar rats with gastric precancerous lesions with a cancer-causing agent model, using the technology of molecular biology in situ method of essays, immunohistochemical method, before and after treatment QLSP group and two control rats gastric precancerous lesions of vascular endothelial growth factor ( VEGF and its receptor, bFGF, PDGF), MVD expression and pathological changes in serum SOD, MDA changes in immune organs (thymus, swelling) weight change. A Results: the clinical research QLSP group before and after treatment markedly effective rate was 32.8%, 80.3% of the head office efficiency; Weifuchun significant efficiency 27.5%, total effective rate 70.0%: Weimeisu significant efficiency of 2.8% of the total efficiency of 47.2%; qLSP group efficiency is significantly higher than the control group. Inhibition of H pylori, elevated blood cAMP, QLSP group, SOD, reduce LPO the improved TXB 2 / 6-K-PGF 1alpha , and the control group were significantly different ( p <0.05). Experimental studies have shown that gastric precancerous lesions of vascular endothelial growth factor expression with the normal group were significantly different (p <0.05). The QLSP group can significantly inhibit the expression and secretion of vascular endothelial growth factor (VEGF and its receptor, bFGF, PDGF, etc.); elevated serum SOD and MDA reduces; blocking or reversal of gastric precancerous lesions of pathological states; significantly increased thymus, spleen weight, and there are significant differences with the control group (p <0.05). Conclusion: spleen and stomach deficiency, blood stasis intrinsic toxicity, the poor must renal chronic atrophic gastritis and precancerous lesions of the main pathogenesis. Therefore, spleen and kidney, qi circulation, relieves congestion detoxification is an important treatment method, qLSP treatment of this disease is not only better clinical efficacy, but the combination of experimental research, as a whole, on the cellular and molecular levels reveals the Treatment of chronic atrophic gastritis precancerous lesions of the mechanism of action. That the role of the drug in multiple aspects of the disease, multiple targets, comprehensive therapeutic effect, the machine may and tumor angiogenesis factor, anti-oxidation, inhibition of lipid peroxidation, immune, improve blood PG1 2 / the TXA 2 balance, inhibition of H D1 bite, anti-inflammatory role, in particular to inhibit the expression of vascular cattle causes, treatment of this disease a new research ideas. The connotation of the rich chronic atrophic gastritis cancer Shantou disease pathology and therapeutics, has made a good attempt.

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