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Astragalus treatment desensitization soup , allergic rhinitis

Author: ZhaoJian
Tutor: ZhouPingAn;SongChongShun
School: Beijing University of Traditional Chinese Medicine
Course: TCM Internal Medicine breathing
Keywords: Astragalus desensitization soup Model of allergic rhinitis T cell subsets Immunoglobulin E interleukin-12 Interleukin-4
CLC: R276.1
Type: PhD thesis
Year: 2005
Downloads: 429
Quote: 0
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Abstract


Allergic rhinitis (AR, allergic rhinitis), is one of the world's most common allergic diseases, especially in the United States, which can be divided into many years seizures seasonal onset or sudden changes in the climate, or inhalation strange The irritants attack; often due to disease and over again, difficult to control, resulting in patient discomfort, thus affecting the patient's social life, affect learning and work, resulting in family and social burden, are increasingly subject to the attention of all aspects. Therefore, the positive development of drug prevention AR important. The Inst teacher many years of clinical experience in the treatment of allergic rhinitis, confirmed that in traditional Chinese medicine to treat the disease, and achieved good results. Astragalus desensitization soup is prepared Chou cumulative years of clinical experience, mainly for the etiology and pathogenesis of allergic rhinitis basic observed protective effect of Astragalus desensitization soup AR animal model study on this basis shape the role of the rat model, and analysis of its mechanism of action, provide a reliable experimental basis for the Astragalus the desensitization soup clinical for AR. And astragalus treatment desensitization soup, 80 Cases of allergic rhinitis and 320 cases of epidemiological investigation in the United States. Experimental observation of Astragalus desensitization soup allergic rat model Astragalus desensitization of the soup of the AR model rat nasal histopathological changes and determination astragalus of desensitization soup on AR model rat blood and nasal mucosal histamine content. The results show that, Astragalus desensitization the soup big, small dose group improved the pathological changes of the AR model rats (P lt; 0.05). Rats pathological change classification scoring visible of Astragalus desensitization soup large, pathological changes in rats of the low-dose group was significantly reduced (P lt; 0.05). Astragalus desensitization the soup big dose group rat blood histamine were significantly reduced, astragalus the desensitization soup large, low-dose group rat nasal histamine were significantly reduced (P lt; 0.05). Astragalus desensitization soup AR rat T subsets and related cytokines and IgE regulation 2.4-dinitrochlorobenzene sensitization experimental rat AR model, respectively by immunohistochemistry (APAAP) radioimmunoassay (RIA) and enzyme-linked immunosorbent (ELISA), the status of the AR model of the rat study was measured before and after treatment blood T lymphocyte subsets (CD4, CD8), total serum IgE levels and TH1/TH2 representatives factor IL-12, IL-4 of the levels. The results show that the high-dose group Astragalus desensitization soup can significantly reduce the AR model serum total IgE content (P lt; 0.05) astragalus soup anti-AR desensitization mechanism of the may be related to the inhibition of serum total IgE levels related. Astragalus desensitization soup high-dose group significantly increased the AR rat model of peripheral CD4-positive rate (P lt; 0.05); increase model of CD8-positive rate of Astragalus desensitization the soup big, small dose group, but with shape control group compared with no significant difference. Astragalus desensitization soup large doses, Biyuanshu, CPM can significantly increase the AR model rat peripheral blood CD4/CD8 ratio (P lt; 0.05). Tip astragalus the desensitization soup anti-AR may be related to one of the mechanisms to regulate the CD4/CD8 the balance. Astragalus desensitization the soup big, small dose group lower AR model of serum IL-4 levels

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CLC: > Medicine, health > Chinese Medicine > Traditional Chinese Medicine ENT > Department of Otolaryngology,
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