Dissertation > Excellent graduate degree dissertation topics show

Studies on Interactions at Interfaces of Phosphorothioate Oligo-DNA and Nanocrystals

Author: JiangLin
Tutor: LiTieJin;YangWenSheng
School: Jilin University
Course: Physical and chemical
Keywords: Nanocrystalline Phosphorothioate Nanostructures Sites of action Induce the synthesis of Side chain Synergy Cancer treatment Phosphate group Base
CLC: O629.7
Type: PhD thesis
Year: 2005
Downloads: 104
Quote: 0
Read: Download Dissertation

Abstract


Thio DNA as an important family of the antisense DNA, are used for various in vitro and in vivo models as the passivation of DNA, and now has been used for anti-viral infection, cancer therapy, AIDS therapy. The phosphorothioate DNA is a phosphate group on the non-bridging O atom is replaced by the S atom to form a chemical bond, it is possible with some of the atoms in the bit, such as Cd, Au, also makes thio DNA molecule into a building having a specific structure and function nanostructure ideal material. This article by to phosphorothioate oligonucleotide nanocrystals interfacial interactions provide new ways and ideas, and try to use the characteristics of such a modified way DNA induced nanocrystalline assembled nanostructures. Side chain thio modified oligo DNA the Cd2 ions and the use of the sites of action of induced synthesis of CdS nanocrystals. Cd2 ions, the thio DNA destruction the pairing of the G base PS-oligoG10 hydrogen bonds, and the role of coordination occurred through the Cd2 from thio DNA of the phosphate thio DNA induces the formation of a special diameter about 2 nm nanospheres; addition of S ion thio the DNA induced synthesis diameter of 5 nm CdS Nanocrystals, but the action sites from phosphate bit transferred to the DNA base sites. Phosphorothioate oligo DNA with the surface of the rich Cd2, rich S2-neutral CdS Nanocrystals interface synergistic interaction process. Negative synergy found CdS Nanocrystals neutral role of the DNA with the surface of the modified oligomers positive synergies rich the CdS nanocrystals role of the S2-surface, and surface rich Cd2 CdS Nanocrystals role No synergistic occurred. The unmodified oligo DNA surface neutral CdS Nanocrystals role positive synergy, but synergy is less than the modified oligomeric DNA. Thio side chain modified oligo DNA Au nanocrystals interfacial interactions found oriented parallel orientation of this side chain modified DNA molecules on the surface of the nanocrystals. The parallel orientation of the side chain modified DNA, can affect the surface of the nanocrystals can be adsorbed amount of DNA and then control the arrangement of the nanocrystals in the assembly. Using four kinds of different lengths of side chain modified DNA molecule, respectively, to obtain a close-packed hexagonal, tetragonal, tripartite and four different linear nanostructure pattern.

Related Dissertations

  1. Preparation of ITO Quai-1D Nanostructures by Sol-Gel Method Combined with Porous Anodic Aluminum Oxide Template,TB383.1
  2. The Research of Mountain Outdoor Sports Base Construction in Zhejiang Daming Mountain Scenic,G895
  3. Preparation of Epichlorohydrin from Crude Glycerol of Biodiesel By-product,TQ223.26
  4. Study on Preparation of Biodiesel Catalyzed by Solid Base,TE667
  5. The Internet of Things Applied Research in Clothing Industry,TN929.5
  6. The Investigation of the Flow Station of ICU Specialist Nurse Training Basement in Xinjiang,R471
  7. The Exploration of Teaching Case Library Creating for Higher Vocational Colleges,TP311.53-4
  8. Study on the Quality Management of the National Base of Training for the Vocational Teachers,G715.1
  9. Synthesis and Asymmetric Catalytic Behaviors of Chiral Imine and Dimines Schiff Bases,O621.3
  10. Theoretical Analysis of the Circular Dichroism Spectra of Transition Metal Schiff-Base Complexes,O641.4
  11. The Study on the Tribological Property of Schiff Base Copper (Ⅱ) Complex in Different Basis Lubricating Oils,TE624.82
  12. EMU maintenance base in Guangzhou Project Management Research,F532
  13. Different metal base and binder zirconia all-ceramic crowns on the color of,R783
  14. Inorganic and inorganic - organic hybrid Zn -based catalysts and catalytic L- lactide ring-opening polymerization of L- polylactic acid applied research,O631.3
  15. 1,4 - bis (4 - amino-2 - (trifluoromethyl) phenoxy ) benzene -type Schiff base imide copolymer synthesis and characterization,O631.3
  16. Schiff base Synthesis, Characterization and Antibacterial Properties,O641.4
  17. Palladium catalyzed guiding purine -purine C6- aryl ( nucleosides ) reaction of aryl,O643.32
  18. Ni / TiO 2 -SiO 2 Preparation, Characterization and Hydrogenation of Maleic Anhydride,TQ225.2
  19. Key Technology Research of Infrasound Source Positioning Based on Wide-Area Sensor Network,TN912.3
  20. Campus e-commerce solutions,TP393.09
  21. Study on the Key Technologies of Domain Database-Oriented Question and Answering System,TP311.13

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Natural compounds > α-amino acids,peptides, proteins, nucleic acids
© 2012 www.DissertationTopic.Net  Mobile