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Study on the Differentiation of MSCs and Effect of MSCs with rAAV-GDNF on the Function Recovery of Spinal Cord after SCI in Rats

Author: WangXiangLi
Tutor: TangJiWen
School: Shandong University
Course: Surgery
Keywords: Bone marrow mesenchymal stem cells Induced differentiation Adeno-associated virus Glial cell line-derived neurotrophic factor Gene therapy Spinal cord injury Evoked potentials
CLC: R651.2
Type: PhD thesis
Year: 2004
Downloads: 221
Quote: 0
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Abstract


Spinal cord injury (spinal cord injury, SCI) is a common clinical disease, severe spinal cord injuries occur in young adults . Traffic injury , fall injury , sports injuries , and catastrophic accidents are a major cause of spinal cord injury , such patients in our country there is a rising trend . Injured young adults with the ability to work , causing great losses to individuals and society , especially severe spinal cord injury in high morbidity , seriously endanger human health . For nearly a hundred years of history of spinal cord injury research , early results show that axonal regeneration after spinal cord injury is very limited capacity for a long time denied the central nervous system has the ability to regenerate . In recent years, studies have shown that certain central nervous system regeneration capacity, but difficult to pass through the area of spinal cord injury the regeneration of axons to re-establish the connection with the distal end effector . Currently, the focus of research scholars at home and abroad focused on two aspects , spinal cord injury ( including primary injury and secondary damage ) mechanism , the second is to explore to find factors that can promote the regeneration of central nervous . It has been shown that electromagnetic stimulation , neurotrophic factors and certain drugs on the spinal cord regeneration promoting effect , but the effect of the treatment is not yet satisfactory , with the development of new technologies in molecular biology , and particularly since 1990, the U.S. National Institutes of Health since the first successful gene therapy for adenosine deaminase deficiency , gene therapy has become the fastest growing areas of existing foreign scholars in biomedical experimental study of gene therapy of spinal cord injury , although this research is still at experimental exploration stage, but with the development of biomedical and some solution to the problem , transgenic technology is expected to become one of the important means to solve this clinical problem of spinal cord injury .

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CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Spinal cord
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