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Study on Theories and Experiments of Signal Acquisition for Non-Invasive Blood Glucose Sensing with Near-Infrared Spectroscopy

Author: ChenWenLiang
Tutor: XuKeXin
School: Tianjin University
Course: Measuring Technology and Instruments
Keywords: Near Infrared Spectroscopy Diffuse reflection Non-invasive measurement Blood glucose concentration Optical probe Contact pressure
CLC: R318.51
Type: PhD thesis
Year: 2005
Downloads: 395
Quote: 16
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Abstract


Diabetes and its complications has become a serious global threat to human health and even the lives of incurable diseases. Blood glucose concentration non-invasive detection technology has no pain, no risk of infection, etc., to achieve real-time monitoring of the blood glucose concentration and guide rational drug for measuring pain, reduce diabetes, has a very important practical significance. Based on this, the subject of human blood glucose concentration near infrared system of non-invasive measurement method. Paper based on the glucose in the various layers of the skin tissue distribution characteristics, the proposed method of using the dermal diffuse reflectance spectroscopy measuring blood glucose concentration. Approximate solution to the steady-state diffusion equation in a semi-infinite medium, analysis of the blood glucose concentration by absorbing and scattering Effects role in the mechanism of energy diffuse reflectance deduced diffuse reflection light with the changes in blood glucose concentration approximate relationship. Based on the measurement principle, the development of near-infrared non-invasive blood glucose concentration detection system applied to the palm of your hand parts. Effective programs pick up the the palm leather diffuse reflectance signal. Monte Carlo analysis of the penetration depth and the distribution pattern of the transmission path length palm diffuse reflectance radial distribution of photons in the organization. And considering the impact factor of the dermal diffuse reflection of the number of photons in the dermis, the effective optical path length for effective leather informative, solving get amount of dermis Information load distribution curve with radial detection distance. Distribution characteristic according to the peak of the curve, there is determined the specific structural parameters of the optical probe. Study the contact pressure affects the mechanism of diffuse reflectance spectroscopy. Starting from the definition of the scattering cross section of the particles and the absorption cross section, the forward Solving the scattering and absorption properties of the tissue to obtain the scattering coefficient and absorption coefficient based on the expression of the tissue thickness. And using the finite element model is calculated from the different contact pressure of the tissue thickness, thereby to obtain the relationship between the scattering coefficient and the absorption coefficient and the contact pressure. Deduced on this basis, the theoretical formula of the dermis diffuse reflected light with the contact pressure changes. Diffuse reflectance spectroscopy measurements of the living body is influenced by the contact pressure of the solution. Through experiments, this paper systematically studied the impact of changes in the contact pressure of diffuse reflectance spectroscopy, and the same contact pressure with the contact time fluctuations characteristic diffuse reflectance spectroscopy. According to the results, first proposed the best contact state and the best measurement of the time of the argument. Spectral acquisition the best measurement conditions, to improve the stability of the spectral measurements. Finally, we conducted a clinical study of non-invasive measurement of human blood glucose concentration. Use improved OGTT (oral glucose tolerance test) acquisition calibration set samples, to establish PLS (Partial Least Squares) correction model and single OGTT experimental samples. OGTT experiment of 50 passengers in the text from the calibration model was evaluated based on fully interactive authentication method, the RMS prediction error for the 0.6773 ± 0.0886mmol / l. The clinical trial results show that the detection method of this article and the effectiveness of the system.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > Other branches of biomedical engineering > Light,laser biomedical
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