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Expression and Change of Calbindin-d28k in Human Female Reproductive System

Author: XuDuo
Tutor: ZhuWeiJie
School: Jinan University
Course: Obstetrics and Gynaecology
Keywords: Human Cancium-binding protein Calbindin-d28k Ovary Fallopian tube Endometrium Salpingitis Hydrosalpinx Ectopic pregnancy Apoptosis Caspase-3
CLC: R711
Type: PhD thesis
Year: 2006
Downloads: 132
Quote: 1
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Abstract


BackgroundCalbindin-d28k (CaBP-d28k) , a kind of calcium-binding protein, belongs to a kind of eucaryotic proteins and 28 kd vitamin D-dependent calcium-binding protein. CaBP-d28k contains EF hand motifs, which have high affinity for Ca2+ ions to a specific helix-loop-helix structure. CaBP-d28k is thought to buffer intracellular calcium levels and plays several important physiological roles. Previous investigations to animals demonstrated that CaBP-d28k played important roles in the events of female reproduction. But to human, there were no fully studies on the relation of female reproduction and CaBP-d28k. Now, the relationship between CaBP-d28k and the physiological and pathological function of female reproduction was still unknown. The presence and localization of CaBP-d28k has not been studied in human fallopian tube and ovary. Studies about CaBP-d28k in human uterus were also rare. Previous studies showed that CaBP-d28k was concerned with the process of implantation. But, whether the etiology of some female infertility ralated the CaBP-d28k was unknown. The expression of CaBP-d28k in human pathological female reproduction, the role of CaBP-d28k in human

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CLC: > Medicine, health > Obstetrics and Gynaecology > Gynecology
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