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Expression Change Group Ⅰ mGluRs in Rat MVN and Flocculus after Unilateral Labyrinthectomy and Expression Change of AChR-M1 in Rat MVN after Unilateral Labyrinthectomy

Author: ZhangYaMin
Tutor: KongWeiJia
School: Huazhong University of Science and Technology
Course: Otorhinolaryngology
Keywords: Unilateral labyrinthectomy resection Medial vestibular nucleus Rats Metabotropic glutamate receptor Muscarinic receptor subtypes in rats
CLC: R764
Type: PhD thesis
Year: 2006
Downloads: 24
Quote: 0
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Abstract


Objective: To observe the expression change of Group I mGluRs in the medial vestibular nucleus(MVN) following left unilateral labyrinthectomy(UL). METHODS: After secting left labyrinthectomy, the change of Group I mGluRs was detected by Immunohistochemistry, In situ hybridization. RESULTS: Group I mGluR5 was induced increase in both side MVN after unilateral labyrinthectomy.By contrast, mGluR1 was induced decrease. However,that of the lesioned side was stronger than that of the unlesioned side. CONCLUSION: UL can induce change in the MVN,The fall in the resting discharge of the primary vestibular afferents and/or in thedeafferented central vestibular neurons may cause the change of mGluRs. But the significance of the change of mGluRs in the vestibular compensation is still un-known. Abstract Objective: Studies revealed that cerebellar flocculus-parafiocculus complex plays an importmant in vestibular compensation.To observe the expression change of Group I mGluRs in flocculus following left unilateral labyrinthectomy(UL). METHODS: After secting left labyrinthectomy, the change of Group I mGluRs was detectedby Western-blot and RT-PCR. RESULTS: Group I mGluR5 was induced increase in both side flocculus after unilateral labyrinthectomy.By contrast, mGluR1 was induced decrease. However,that of the lesioned side was stronger than that of the unlesionedside. CONCLUSION: UL can induce change in the MVN,The fall in the resting discharge of the primary vestibular afferents and/or in the deafferented central vestibular neurons may cause the change of mGluRs. But the significance of the change of mGluRs in the vestibular compensation is still un-known. Objective: To observe the expression change of Ml Muscarinic receptors in the medial vestibular nucleus(MVN) following left unilateral labyrinthectomy(UL). METHODS: After secting left labyrinthectomy, the change of Group I mGluRs was detected by Immunohistochemistry and Western. RESULTS: Ml was induced increase in both side MVN after unilateral labyrinthectomy. However,that of the lesioned side was stronger than that of the unlesionedside. CONCLUSION: UL can induce change of Ml in the MVN,The fall in the resting discharge of the primary vestibular afferents and/or in the deafferented central vestibular neurons may cause the change of M1. But the significance of the change of M1 in the vestibular compensation is still un-known.

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