Dissertation > Excellent graduate degree dissertation topics show

Study on Synthesis of 2,6-Substitute Purine Derivatives

Author: LuHongFei
Tutor: LvChunXu;LuMing
School: Nanjing University of Technology and Engineering
Course: Applied Chemistry
Keywords: Purine Substitute Synthesis Fluorine Trifluoromethyl Trifluoroethoxyl Fungicidal activities
CLC: O626
Type: PhD thesis
Year: 2006
Downloads: 395
Quote: 0
Read: Download Dissertation

Abstract


Purine derivatives are a kind of important semi-pharmic of nucleotide. During thispaper, lots of purine derivatives are synthesized from the material of guanine. Thefactors that can influence reaction are studied by the numbers.Guanine as the raw material, during the acetic acid and acetic anhydride,N2·9-diacetylguanine are prepared under the condition of 135℃, the yield is 95.6%.Through chloridization and hydrolyzation, 2-amino-6-chloropurine is prepared, then,through halogen exchanging, 2-amino-6-halogenpurine derivatives are prepared.Through the calculation of quantum chemistry by the procedure of Guass98, thereaction activity of the four purine derivatives has been come out. 2-amino-6-chloro-purine as the raw material, during the organic solvent of DMF, through alkoxylatereaction, 2-amino-6-alkoxypurine derivatives are prepared. 2-amino-6-chloropurine asthe raw material, during the organic solvent of DMF, 2-amino-6-aminogroupsubstitutepurine derivatives are prepared. 2-amino purine derivatives as the raw material, usingNaNO2, through diazotization, 2-halogenpurine derivatives are prepared. Thecalculation of quantum chemistry by the procedure of Guass98 shows that the existingof electron-donating group in C6 can make the substitution by bromine and chlorine easier andget higher yield, and it also shows that the existing of electron-acquired groups in C6can make the substitution by iodine and fluorin easier and get higher yield. 6-chloropurinederivatives as the raw material, 6-fluoropurine derivatives are prepared under thecondition of dry DMSO and dry KF. 6-bromopurine derivatives as the raw material,6-trifluoromethylpurine derivatives are prepared under the condition of dry DMF anddry NaOOCCF3 and CuI. 6-chloropurine derivatives as the raw material,trifluoroethoxylpurine derivatives are prepared under the condition of dry DMF anddry NaOH2CCF3.Bacillus subtillis, Aspergillus niger and Cardida tropical are selected to test thefungicidal activities of purine derivatives. Purine derivatives was confected tosolution of 3*10-5 g/mL by sodium hydroxide solution(1 weight% in water), and thenmeasured the diameter of fungistatic circle.

Related Dissertations

  1. Studies on the Synthesis and Technology of Dipentaerythritol and Its Derivative,TQ223.164
  2. Synthesis and Characterization on Semi-Aromatic Polyamides Containing Benzoxazole Units,O633.5
  3. Hydrothermal Synthesis of Oxide Hollow Spheres,TB383.4
  4. Video Coding Research Based on Texture Characteristics,TP391.41
  5. Poetic alienation : graphics,J506
  6. Urothermal Synthesis, Structure and Characterization of Functional Coordination Polymers,O631.3
  7. The Total Synthesis of a Flavonoid Glycoside Apigenin-7-O-β-D-glucuronide,R284.1
  8. Atovaquone analogues Design, Synthesis and antitumor activity of,R914
  9. Synthesis and Seperation of 1,1’-binaphthol,O625.3
  10. Flexible,rigid,Synthesis and characterization of mixed ligand complexes,O621.1
  11. Synthesis and Performance Study of Bisphenol AP-based Polybenzoxazines,TQ320.1
  12. The Resistance and Resistance Chemical Control of Japanese Foxtail (Alopecurus Japonicus Steud.) to Haloxyfop-R-Methyl and Its Cross Resistance, Multiple Resistance with Different Herbicides,S451.2
  13. Gold-catalyzed Addition Reaction of Sulfonates and Alkynes and Study of Synthesis and Bioactivity of (E)-3-phenyl-substituted Acrylic Acids,R914
  14. Synthesis and Identification of P22/P221 Polypeptides of IBDV Ligand Epitope and Screening CEF Library,S852.65
  15. Curing Mechanism and Properties of Fluorenyl Epoxy Resin,TQ323.5
  16. Syntheses of Novelbenzopyran Compounds Containing Fluorine and Induced Resistance to TMV,S435.72
  17. Research on the Physiology Mechanism of Grain Filling of inferior Grain during Day and Night Chemical Regulations,S511
  18. Expression of β-Catenin in Pig’s Ovary and the Effect of β-Catenin on Porcine Granulosa Cells Apotosis and Steroidogenesis Related Enzyme,S828
  19. Synthesis and Reactions of Organo Lithium, Potassium, Magnesium Compounds,O621.13
  20. Synthesis and Biological Activities of 3-(1’-Alkyloxycarbonylmethylimino) Ethyl-4-Hydroxypyrroline-2-One Derivatives,TQ463.5
  21. Containing pyridyl group metal complexes Synthesis and Structure,O627

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Heterocyclic compounds
© 2012 www.DissertationTopic.Net  Mobile