Dissertation > Excellent graduate degree dissertation topics show

Influence on Haematopoietic Adherent Transduction Signal PI-3K, JNK of CAA Patients and Correlation Factor Treated by Invigorating the Kidney and Hemogenesis Method

Author: WangJingBo
Tutor: SunWeiZheng
School: Heilongjiang University of Traditional Chinese Medicine
Course: Traditional Chinese Medicine
Keywords: CAA Invigorating the kidney and hemogenesis method Busui Shengxue Granule PI-3K JNK VLA-4/CD49d IL-6 TNF-α
CLC: R259
Type: PhD thesis
Year: 2008
Downloads: 97
Quote: 0
Read: Download Dissertation


Objective:To observe effects on CAA clinical therapeutic effect, influences on haematogenesis adhesion transduction signal PI-3K,JNK, correlation factor VLA-4/CD49d.IL-6,TNF-α,and to approach the mechanism of action on Chinese herbal medicine with invigorating the kidney and hemogenesis function treating CAA.Methods:Sixty patients of CAA were divided into two groups at random, treated group(treated with Busui Shengxue Granule)and control group(treated with Aplastic Blood-Forming Tablet).Another 10 healthy volunteers were treated as normal control group.We compared with clinical therapeutic effect, periphery hemogram,myeloid gram in the two groups,and detected expression of PI-3K,JNK by Western blot.Then we detected VLA-4/CD49din marrow mononuclearcell prior and post treatment by FCM,IL-6,TNF-αin serum by ELISA.Results:(1)The total effective rate of Busui Shengxue Granule and Aplastic Blood-Forming Tablet were 73.3%and 53.3%,and after statistical treatment, the comparison between the two groups showed significant difference(p<0.05).(2)It showed superior therapeutic effect on deficiency of kidney-YANG type to deficiency of kidney-YIN type treated by Busui Shengxue Granule, whicn indicated significant difference in statistics(p<0.05).(3)Levels of PI-3K in MSC of CAA patients were lower than normal control group in prior treatment(p<0.05);and Busui Shengxue Granule could increase PI-3K expression(p<0.05),but still lower than normal control group.It also expressed superior in deficiency of kidney-YANG type to deficiency of kidney-YIN type(p<0.05).(4)Levels of JNK in CAA patients’ MSC were higher than normal control group in prior treatment(p<0.05),Busui Shengxue Granule could reduce JNK expression(p<0.05),and it showed more significant in deficiency of kidney-YANG type(p<0.05).(5)VLA-4/CD49din marrow mononuclearcell in CAA patients expressed lower than normal control group in prior treatment(p<0.05),but VLA-4/CD49d expression rose after treating by Busui Shengxue Granule(p<0.05),also it showed more significant in deficiency of kidney-YANG type than deficiency of kidney-YIN type(p<0.05).(6)In prior treatment,levels of IL-6,TNF-αin serum of CAA patients were both higher than normal control group(p<0.05).After treating by Busui Shengxue Granule,the levels of IL-6,TNF-αboth reduced(p<0.05),and it showed more significant in deficiency of kidney-YANG type(p<0.05).Conclusions:Busui Shengxue Granule was superior to Aplastic Blood-Forming Tablet on clinical curative effect of treating CAA,so it was an active drug preventing and curing CAA,and also the curative effect by Busui Shengxue Granule expressed superior in deficiency of kidney-YANG type to deficiency of kidney-YIN type.Expressions on haematogenesis adhesion transduction signal PI-3K,JNK,adhesion molecule VLA-4/CD49d,and cytokine IL-6,TNF-αshowed abnormal,which might closely correlate with CAA.Busui Shengxue Granule might cure CAA by improving expressions of haematogenesis adhesion transduction signal,adhesion molecule and cytokine.

Related Dissertations

  1. Inhibition of RAW264.7 Macrophage Inflammatory Cytokines Release by Guggulsterone,R285
  2. Infectious Bursal Disease Virus Particle Vaccine Research and Its Immune Efficacy Evaluation,S858.31
  3. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  4. Preparation of Monoclonal Antibody to Porcine TNF-α and Expression of TNF-α in PAM Infected with PRRSV,S858.28
  5. Live alone the study of parasitic soup rabbit lumbar disc herniation model in vivo tumor necrosis factor in rats,R285.5
  6. The Expression and Significance of Nuclear Factor Kappa B (NF-κb) and IL-6 in the Degenerated Cervical Intervertebral Disc,R681.55
  7. Cysteamine on T Lymphocyte Proliferation in Post-Operation Goats and Its Mechanism Underlying,S858.27
  8. Cloning, Expression and Bioactivity Analysis of Goat Interleukin-1β and Interleukin-6,S827
  9. Meridians of Asthma Thread Burying Model Rats IL-4 Such Impact Experimental Study,R245
  10. Role of G31P in Smooth Muscle Migration of A7r5 Cells Induced by Interleukin-8,R363
  11. The Expression and Mechanism of NF-κ B and IL-6 after 90% Portal Vein Ligation in Rats,R657.3
  12. The Sequence Analysis of RNA Components from Lactobacillus Metabolites and Parts of the Biological Function,R378
  13. Noble Dendrobium Polysaccharides Attenuate Learning and Memory Deficits Induced by Lipopolysaccharide and Its Mechanisms in Rats,R285.5
  14. Effect of Grape Seed Procyanidins on the Blood Pressure in Renovascular Hypertensive Rats and Its Mechanism,R544.1
  15. Experimental Study on 420nm Intense Pulse Light in Animal Acne Model,R758.733
  16. Biological Effects of Soluble CD40 Ligand on Leukemia HL-60 Cells and Its Mechanism,R733.7
  17. The Regulatory Role of Proliferation and Apoptosis of ERK1/2 and JNK Signaling Pathways in Eight Liver Cell Types during Rat Liver Regeneration,Q418
  18. Cloning and Expression Analysis of NCCRP-1 AND IL-10 Genes in Grass Carp (Ctenopharyngodon Idellus),S917.4
  19. Clinical Observation of Ditan Soup in Treating PSD,R277.7
  20. Exploreing the Mechanism of Xieshifeiaifang Ii on Treating Lung Cancer with Pleura Effusion,R734.2
  21. Study on the Correlation Between the Levels of Il-18, IL-33 and Other Inflammatory Factors and Pulmonary Function in Different Stages of Asthma,R562.25

CLC: > Medicine, health > Chinese Medicine > TCM Internal Medicine > Modern medicine, internal diseases
© 2012 www.DissertationTopic.Net  Mobile