Dissertation > Excellent graduate degree dissertation topics show

Design and Synthesis of Chiral Solvating Agent and Pattern-based Recognition for Determination of Enantiomeric Excess Using NMR

Author: LiuLu
Tutor: LeiXinXiang; YuXiaoChun
School: Wenzhou University
Course: Organic Chemistry
Keywords: Chiral recognition Pattern Recognition Enantiomeric Excess NMR chiral Carboxylic Acids Lansoprazole
CLC: O657.2
Type: Master's thesis
Year: 2012
Downloads: 21
Quote: 0
Read: Download Dissertation


The NMR is an important and useful tool in chiral recognition. Theutility model has obviously advantages: the product without separationand purification, be rapidly determinated, and environment friendly. Inthis paper, a series research has been done focus on the theme. The thesiscan be divided into the following parts:1. A series of chiral salan C2-symmetric aminophenols1-7, whichwere derived from (1R,2R)-or (1S,2S)-1,2-diphenylethane-1,2-diaminewith the corresponding salicylic aldehyde through a [2+2] condensationreaction, have been prepared. The NMR studies demonstrated that theycan function as chiral solvating agents for the determination of theenantiomeric purity of chiral α-hydroxy carboxylic acids.2. A protocol for the determination of enantiomeric excess of chiraldrug, such as Lansoprazole, using the subtle frequency shifts (chemicalshift perturbation) in NMR spectra induced by chiral auxiliaries(R-Binol,quinidine, cinchonine), is described. The spectra were analyzed with twopattern recognition protocols. Principal component analysisdemonstrated good enantioselective separation of the analytes, andpartial least-squares was used to analyze ee. values of unknown samples.We believe that this method combines several attractive features: itdepends on commercially accessible chiral auxiliaries that arenonspecific, avoids substrate derivatization and minimizes solvent waste,and it supplies a new method for determing the chiral purity of chiraldrugs. Therefore, this result provides a new insight to refining andexpanding the applications of existing chiral solvating agents for enantioselective analysis.

Related Dissertations

  1. Intrusion detection based on the ultrasonic echo envelope in the military security patrols,E919
  2. Study on the Properties of Polyphosphatases from Beef Semitendinosus and the Enzymic Reaction Systems,TS251.1
  3. Effective active ingredient with skullcap calixarene supramolecular inclusion complexes of,R284
  4. 3 - hydroxybutyrate , and 3 - ( 2,2,2 - trifluoro- acetoxy ) ethyl butyrate, and PMBCD chiral Theoretical Study,O621.25
  5. Experimental and Molecular Simulational Study on Phillips CrOx/SiO2 Catalysts for Their Active Center and Polymerization Mechanisms,TQ325.12
  6. Effects of Antibacterial Drugs on Lansoprazole Metabolism in Vitro and in Vivo,R96
  7. Researches on the Damage Mechanism of Fracturing Fluid to the Low Permeability Sandstone Gas Reservoir,P618.13
  8. Synthesis of L-Leucine and Ferrocene Derivants and Their Recognition of Chiral Carboxylic Acids,O621.3
  9. β-Cyclodextrin-Naproxen Inclusion Complex and Its NMR Characterization,O636.1
  10. Study on the Solvent-free for Allylation Reactions of Carbonyl Compounds and Prins Cyclization Mediated by Magnesium Powder,O621.25
  11. Utilization of 2-Amino-4-aryl-6-arylnicotinamides in the Synthesis of Some Novel Heterocycles under Microwave Irradiation,O621.3
  12. Novel Chitosan-based Sydrogels and Their Gelation Mechanism Investigations,O648.17
  13. The Research on the On-line Revising Algorithm for the Industrial Power Proportion Based on Daily Load Profile,TM714
  14. Research on Chlorogenic Acid and Flavonoids from Eucommia Ulmoides Leaves: Extraction, Isolation, Purification and Structural Identification,TQ461
  15. Application Research of Fuzzy Neural Network in Elevator Group Control System,TP273.4
  16. The Classification of High Dimsnsion Flew Field Based on Manifold Learning,V231.3
  17. Research on Intelligent Control Strategy of Flatness for Tandem Cold Mill,TP273.5
  18. Design and Implementation of the steel structure special welding non-destructive testing and defect signal recognition system,TP274
  19. Study on Diagnosis System of Traditional Chinese Medical Tongue Image Based on Digital Image Processing,R241
  20. Windproof and skullcap exclusive control substance research,R282
  21. Studies on the Chemical Constituents of Xanthopappus Subacaulis C.Winkl. and Clerodendrum Japonicum (Thunb.) Sweet,R284

CLC: > Mathematical sciences and chemical > Chemistry > Analytical Chemistry > Instrument analysis ( physics and physical chemistry ) > Magnetic chemical analysis
© 2012 www.DissertationTopic.Net  Mobile