Dissertation > Excellent graduate degree dissertation topics show

Amorphous Ru Alloy Catalyst Used for the Study of Perindopril Intermediate Preparation of the Application

Author: WangYuXiang
Tutor: ZhaoYaJuan
School: Wenzhou University
Course: Applied Chemistry
Keywords: Amorphous alloy Ru-B/Al2O3 Catalyst (2S,3aS,7aS)-octahydroindoline-2-carboxylic acid
CLC: O621.36
Type: Master's thesis
Year: 2012
Downloads: 13
Quote: 0
Read: Download Dissertation

Abstract


Perindopril is a non-sulfhydryl ACE inhibitor, is mainly used for the treatment of essential hypertension and heartfailure, which not only has the advantage of other ACE inhibitors but also the role of longer, smaller side-effects,tolerancebetter, so it has a good market prospects. Currently, no the perindopril industrial production process in thecivil, the development of its high efficiency, low pollution, the synthesis process is necessary. There were a a lot of routesabout the synthesis of (2S,3aS,7aS)-octahydroindoline-2-carboxylic acid, by the indole-2-carboxylic acid ethylesterwas prepared (2S,3aS,7aS)-ioctahydrondoline-2-carboxylic acid, become a hot topic in line with the advatages of atomeconomy and environment-friendly.Amorphous alloy is a new type of catalytic material developed in recent years. Its nature between crystalline andamorphous substances, the structure of the performance with superior catalytic performance for the short-range orderand long range disorder. Meanwhile, amorphous alloy catalyst preparation is simple, less environmental pollution, andeasy to control reaction conditions, those in line with the development trend of today’s chemical production of greendevelopment as a new type of hydrogenation catalyst has important theoretical significance and practical value.In this paper, indole-2-carboxylic acid ethyl ester as the raw material, amorphous alloy Ru-B/Al2O3as a catalyst,hydrogen as a reducing agent, via the catalytic hydrogenation, and obtaine (2,3a,7a)-tetrahydro indole-2-carboxylicacid ethyl ester, the best technology as follows: reaction temperature is100℃, hydrogen pressure is6MPa, reaction time4h, after hydrolysis, split and second hydrogenation reaction, obtain the target product (2S,3aS,7aS)-indoline-2-carboxylic acid, the final yield can reach28%.

Related Dissertations

  1. The Study of Anode Catalyst Pd/C for Direct Formic Acid Fuel Cell,O643.36
  2. Study on the Synthesis of the Polypyrrole-Cobalt Oxides and Their Catalytic Behavior for the Electroreduction of H2O2,O643.32
  3. MCM-41 as aryl oxime palladium catalyst and catalytic Suzuki coupling reaction of aryl,O643.36
  4. Spandex fabric household cleaning catalyst and mechanism of the BLA,TS190.1
  5. Low-Frequency Magnetic Pulsing Effect as Well as EET Study of Amorphous Alloy Fe43Co43Hf7B6Cu1,TG139.8
  6. Study on Microstructure and Performance of Laser Cladding Ni-Based Amorphous Alloy Coatings,TG174.4
  7. Asymmetric Michael Addition of 5H-Oxazol-4-ones to α,β-Unsaturated Ketones Catalyzed by Novel Primary Amine Catalyst,O621.25
  8. Studies on Catalytic Combustion of Chlorobenzene and Dichloromethane Over Ru/Ce-Al2O3 Catalysts,O643.36
  9. Use Composite Oxide Synthesis of Vanillin,TQ655
  10. Catalytic Study of Hydrogen Peroxide Synthesis Directly from H2 and O2,TQ123.6
  11. Catalysts for Synthesis of Poly (Trimethylene Terephthalate) by Direct Esterification,TQ316.31
  12. Synthesis of Metel Complexes of Mimic Enzyme Containing Macrocyclic Triamine Lignd and Its Application in Low Temperature Bleaching of Cotton Fabric as Catalyst for H2O2,TS192.23
  13. Research on Catalytic System for Carbonylation of Butadiene to Methyl 3-Pentenoate,TQ225.146
  14. Henry Reaction to Construct Fluorinated Quaternary Carbon Center,O621.25
  15. Synthesis of Manganese Complex of Briding Macrocyclic Polyamine and Analysis of Its Catalytic Activity in Low Temperature Bleaching Cotton Fabric Using H2O2 as Oxidant,TS192.2
  16. Experimental Study on the Behavior of Coal Gasification by TGA,TQ541
  17. Cotton fabrics cryogenic hydrogen peroxide bleaching system research,TS192
  18. Study on Preparation and Characterization of Acidic Microspheric Catalyst with PVA as Carrier,O643.36
  19. Study on the Preparation and Denitration Properties of Honeycomb SCR Catalyst,O643.36
  20. Hydrodehalogenation of Doxin-like Compounds in Aqueous-organic Biphase System,X13
  21. Electrochemical Generation of H2 for Catalytic Hydrodechlorination of Chlorinated Organic Compounds in Groundwater,X523

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Synthetic organic chemistry > Heavy organic synthesis or catalytic organic synthesis
© 2012 www.DissertationTopic.Net  Mobile