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Amorphous Ru Alloy Catalyst Used for the Study of Perindopril Intermediate Preparation of the Application

Author: WangYuXiang
Tutor: ZhaoYaJuan
School: Wenzhou University
Course: Applied Chemistry
Keywords: Amorphous alloy Ru-B/Al2O3 Catalyst (2S,3aS,7aS)-octahydroindoline-2-carboxylic acid
CLC: O621.36
Type: Master's thesis
Year: 2012
Downloads: 13
Quote: 0
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Perindopril is a non-sulfhydryl ACE inhibitor, is mainly used for the treatment of essential hypertension and heartfailure, which not only has the advantage of other ACE inhibitors but also the role of longer, smaller side-effects,tolerancebetter, so it has a good market prospects. Currently, no the perindopril industrial production process in thecivil, the development of its high efficiency, low pollution, the synthesis process is necessary. There were a a lot of routesabout the synthesis of (2S,3aS,7aS)-octahydroindoline-2-carboxylic acid, by the indole-2-carboxylic acid ethylesterwas prepared (2S,3aS,7aS)-ioctahydrondoline-2-carboxylic acid, become a hot topic in line with the advatages of atomeconomy and environment-friendly.Amorphous alloy is a new type of catalytic material developed in recent years. Its nature between crystalline andamorphous substances, the structure of the performance with superior catalytic performance for the short-range orderand long range disorder. Meanwhile, amorphous alloy catalyst preparation is simple, less environmental pollution, andeasy to control reaction conditions, those in line with the development trend of today’s chemical production of greendevelopment as a new type of hydrogenation catalyst has important theoretical significance and practical value.In this paper, indole-2-carboxylic acid ethyl ester as the raw material, amorphous alloy Ru-B/Al2O3as a catalyst,hydrogen as a reducing agent, via the catalytic hydrogenation, and obtaine (2,3a,7a)-tetrahydro indole-2-carboxylicacid ethyl ester, the best technology as follows: reaction temperature is100℃, hydrogen pressure is6MPa, reaction time4h, after hydrolysis, split and second hydrogenation reaction, obtain the target product (2S,3aS,7aS)-indoline-2-carboxylic acid, the final yield can reach28%.

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CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Synthetic organic chemistry > Heavy organic synthesis or catalytic organic synthesis
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