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Study on the Hydrophobic Modification of Bletilla Striata Polysaccharide

Author: BiYaJing
Tutor: WangYanPing
School: Yanbian University
Course: Pharmacy
Keywords: Bletilla striata polysaccharide hydrophobic modification cholesterolsuccinate substitution degree
CLC: R283
Type: Master's thesis
Year: 2013
Downloads: 3
Quote: 0
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Abstract


Bletilla striata polysaccharide, as a kind of natural polysaccharide, which extracted from bletilla striata, has a strong water-soluble. It is not easy to Bletilla striata polysaccharide to entrap hard-soluble drugs, because its skeleton is easy to be corroded, its poor controlled release effect, and the lack of hydrophobic regions.In order to gain amphipathic compounds, hydrophobic modification Bletilla striata polysaccharide were prepared through cholesteryllation method. Cholesterol succinic were used as the starting materials, which reacted with bletilla striata polysaccharide to afford cholesterol succinyl Bletilla striata polysaccharide. Four different substitution degree of cholesterol succinyl Bletilla striata polysaccharide were synthesized by changing the amount of cholesteryl succinate. The structures of the desired compounds were characterized by IR. We have determined the molecular weight of the compounds by Sepfadex chromatography(HPGPC) and researched their properties by the pharmacopoeia.We have prepared hydrophobic modification Bletilla striata polysaccharide successfully, and synthesized cholesterol succinyl Bletilla striata polysaccharide firstly, the structures were not reported previously. The optimum synthesis process was explored, and we got the best method:catalyst ratio:0.57/0.25, activation time:2h, reaction time:48h. We synthesized different substitution degree of cholesterol succinyl Bletilla striata polysaccharide and determined the molecular weight of the compounds:272897Da,276312Da,285456Da,289987Da. The structures of the compounds were characterized by IR, we got significant enhancement in absorption peak3000-2800cm-1and1700cm-1. It confirmed that we have synthesized successfully.The critical micelle concentration(CMC) of modified Bletilla striata polysaccharide was determined by steady-state fluorescence probe method, and we got the CMC of cholesterol succinyl Bletilla striata polysaccharide whose substitution degree is10%:0.006mg·mL-1.The method of hydrophobic modification is feasible, and the yield of compounds is stable. Reached the experimental design objective basically.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese medicine processing,preparation
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