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Synthesis, Characterization and Properties of the Open-loop Multi-nitrogen Complexes

Author: XuJie
Tutor: PanZhiQuan；ZhouHong
School: Wuhan Institute of Technology
Course: Inorganic Chemistry
Keywords: Open-loop complexes Schiff base complexes Electrospray ionization mass spectrometry DNA cleavage and binding
CLC: O641.4
Type: Master's thesis
Year: 2011
Downloads: 31
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Abstract


This article select the hydroxyl-containing open chain nitrogen complexes study, synthesis, characterization and properties of multi-nitrogen complexes as the main content, target unique synthesis of polynuclear complexes synthesized six new open-loop complexes material: mononuclear complexes [Ni (L 1 ) 2 ] · 2 (CH 3 OH) 1, [Ni (L 2 ) 2 ] · 2 (CH 3 OH) 2, [Cu (L 3 ) 2 < / sub>] 3, tetranuclear complex [(L 4 ) Cu 4 ] 2 4 [(L 5 < / sup>) Ni 2 Mn 2 ] 5 and dual-core complexes [Cu (L 6 ) Cl 2 ] 2 6. And they carried out a series of structural characterization, such as infrared spectroscopy, electrospray ionization mass spectrometry, elemental analysis and X-ray single crystal diffraction. Single crystal structure, six complexes with cyclic voltammetry and magnetic susceptibility experiments to study the electrochemical properties of the complexes and magnetic properties. And Complex 1, Complex 2 Complex 3, with the object 5, and the interaction of the CT-DNA and cutting pBR322 DNA the activity were investigated. The main work is as follows: 1. Ethanolamine and 5-F salicylaldehyde or 5-Cl salicylaldehyde condensation reaction of synthesis of the open chain of the hydroxyl group-containing the polyaza Schiff base complexes. Complexes, the complexes are mononuclear Ni (Ⅱ) complexes. Ni (II) of the ligand environment can be seen as a distorted octahedral geometry. By strong hydrogen bonds between molecules to form an infinite one-dimensional structure. Complexes 1, is very similar to the structure of the complex 2, only the different substituents on the phenyl ring, a substituted group is F 2 of the substituted group is Cl. PBR322 DNA with CT-DNA interactions and cutting activity, although their cutting mechanism are proteolytic cleavage, but different from the effect of cutting, the cutting effect of the complexes substituted with F better. Complex cyclic voltammetry study found that the complex exists a reversible redox peaks. With NaBH 4 revert to ethanolamine ,5-F salicylaldehyde Schiff base was synthesized, the resulting copper amine complex 3 spatial structure and a slightly different complexes, in the its cleavage activity study found that complexes of DNA cutting effect than a better. Ethanolamine, isopropanolamine ,5-F salicylaldehyde as raw materials to prepare a multi-core type complexes, complexes 5 and complexes. Complexes 4 is a cubane-type Cu 4 O 4 core copper - oxygen cluster of quad-core copper complexes. Cu 4 O 4 is a distorted cube. Between complex molecules and intramolecular hydrogen bonds between molecules mainly rely on uncoordinated water molecules to form hydrogen bonding interactions link up to form an infinite one-dimensional chain structure. Complexes 5 a containing Ni 2 the Mn 2 heteropolynuclear complex spatial structure is relatively new, the literature reports no similar structure. Each metal ion coordination environment is not the same. Ni (Ⅱ) and Mn (Ⅱ) by two acetic acid molecules bridge linking. Not only molecular memory in rich hydrogen bonding interactions, intermolecular hydrogen bonds with two methanol molecules form a one-dimensional chain structure. DNA interaction experiments show that the complexes have good cleavage activity and to cut significantly increase with the improvement of the concentration of complexes, by the interaction of the complexes with DNA UV-visible spectrum changes speculate its role as the insert mode. Complex 6 is a by diclofenac bridging Schiff base complexes, in which two copper ions in the two chlorine bridging. The coordination environment of each Cu ions can be seen as a distorted square pyramidal structure. Complex 6 cleave DNA activity increased with the increase in concentration of complexes cutting effect some improvement.

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CLC: > Mathematical sciences and chemical > Chemistry > Physical Chemistry ( theoretical chemistry ),chemical physics > Structural Chemistry > Complex chemistry ( coordination chemistry )
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