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Experimental study on the effect of active atherosclerotic rabbit panacea for induced by high fat diet

Author: ZengShuHui
Tutor: LiXingGuang
School: Beijing University of Traditional Chinese Medicine
Course: Clinical in medicine
Keywords: High-fat diet Atherosclerosis HLXLD Lovastatin
CLC: R285.5
Type: Master's thesis
Year: 2012
Downloads: 164
Quote: 1
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Abstract


In China with economic society development, people’s traditional way of life and the diet structure change, the incidence of cardiovascular diseases are already in the incidence of chronic disease in. Experts have predicted that the global range because of cardioascular death toll could reach the disease death toll from36%.So the cardiovascular diseases is now and in the future for a very long time and human must confront and resolve the most important public health issue. In cardiovascular diseases, atherosclerosis, and its complications accounts for a large part of the scale. After long-term research, human for atherosclerosis complications and have a certain understanding of, in the prevention, diagnosis and treatment has obtained the certain effect, but the distance for this disease completely also has the very big disparity.Domestic of atherosclerosis and its complications of deep system began to research in the1950s, the relevant departments have carried out the epidemiology, clinical and laboratory research, from the population level to the whole, organ level to cell and molecular level, to the present genome and functional genomics level, clinical and laboratory study many results also got the seal of research group. People gradually got agree that, atherosclerosis is a by a variety of genetic and environmental factors that work together, is a process of intervention. Atherosclerosis is a serious harm human health of disease.Now think and atherosclerosis related factors of family genetic, age, diet structure, high blood pressure, smoking, excessive drinking, mental factors. And along with the age growth rates will increase. Along with our country atherosclerosis incidence is increasing year by year, western medicine treatment at present atherosclerosis, there are certain difficulty, so in traditional Chinese medicine research field atherosclerosis mechanism, and guiding traditional Chinese medicine clinical treatment is particularly important. Blood stasis syndrome mechanism nowadays clinical practice combined with modern medicine of atherosclerosis formation mechanism of understanding, think atherosclerosis and the formation and development of blood stasis resistance has a close connection. Blood stasis syndrome as arterial congee, one of the main basis of pathology of atherosclerosis, at present about formulas for activating blood circulation and eliminating stasis treatment atherosclerosis experiment and clinical study reports very many, but its targeted how to deserves further investigation.Atherosclerosis in Chinese medicine belongs to the category of qi stagnant blood stasis. One of the main treatment method for activating blood circulation and eliminating stasis. The experiment through the high fat feeding arterial congee establish rabbit, hardening model, to observe for activating blood circulation and eliminating stasis representative party:loose effect no on experimental atherosclerotic lesions influence, this paper discusses the blood stasis syndrome atherosclerosis pathological mechanism, and the loose effect no effort of atherosclerosis and pathology of the card for further study to intervention role atherosclerosis card the reason and clinical syndrome differentiation and treatment to provide theoretical and experimental basis.Purpose:Through the animal experimental observation loose effect no resistance to rabbit atherosclerosis the function and form of serum total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol (hdl-c), low density lipoprotein bravery solid drunk (LDL)-C), apolipoprotein A1(APO-A1), apolipoprotein B (ApoB) level of influence.Methods:1. Using high fat feed copy of the feeding of atherosclerosis model, to observe the changes of blood fat. High fat diet cause experimental rabbit hyperlipidemia. The rabbit to cholesterol, high-density lipoprotein cholesterol(hdl-c), aortic wall of coronary pathological structure system observation.2. Using high fat feed copy of the feeding of atherosclerosis model. Western medicine are taking "los crestor d" and take Chinese traditional medicine "loose effect no" between total cholesterol, triglyceride, high-density lipoprotein cholesterol (hdl-c), apolipoprotein APO-A1, APO-B blood sugar; Weight change between groups.Results:1. High fat feed feeding can induce model rabbit aorta atherosclerotic lesions produce.2. Loose effect can make the model of the best rabbit aorta AS pathological changes to reduce.3. Loose effect no can make ApoA-1, hdl-c (P<0.05) can make LDL-C, TC, ApoB, level to decrease (P＜0.05).Conclusion:Traditional Chinese medicine has a good effect in the loose all of atherosclerosis role. this probably with its can be effectivcly adjust the lipid levels.

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