Dissertation > Excellent graduate degree dissertation topics show

Association of Coagulation Factor Ⅶ Gene Polymorphisms and Its Plasma Activity Levels with Venous Thromboembolism

Author: MuFuNaYi·AiErKen
Tutor: AiLiMan.MaHeMuTi
School: Xinjiang Medical University
Course: Internal Medicine
Keywords: coagulation factor Ⅶ mutation single nucleotid venous thromboembolism
CLC: R543.6
Type: Master's thesis
Year: 2013
Downloads: 2
Quote: 0
Read: Download Dissertation

Abstract


Objective:To investigate the coagulation factor Ⅶ gene R353Q mutation andplasma FⅦa levels in patients with venous thromboembolism.Methods:198patients(including86males and112females, mean age (54.39±15.37) years) diagnosed by VTEwere admitted by the First Affiliated Hospital of Xinjiang Medical University betweenJanuary2008and June2012,and212population(including104males and108females,mean age (53.15±14.53) years) were studied as controls. Polymerase chainreaction-restriction fragment length polymorphism (PCR-RFLP) was applied to detect thepolymorphism of FⅦ gene R353Q and enzyme-linked immuno sorbent assay wasadopted to determine the plasma FⅦa levels, and the association of the polymorphism ofFⅦ with VTE was analyzed.Results:①The frequencies of RR, RQ and QQ were72.73%,26.76%and0.51%in the VTE group while those were74.06%,25.47%and0.47%in thecontrol group. There were no significant differences in the SNP genotyping distributionfrequency between controls and VTE patients (P>0.05).The R-allele frequency (86.11%vs.86.79%) and Q-allele frequency (13.89%vs.13.21%) in the VTE group and controlgroup showed not statistically significant differences, respectively(P>0.05).②Plasma FⅦa levels in VTE group were significantly higher than controls(VTE group:234.39±89.33pg ml,control group:103.60±33.62pg ml,P=0.000). In VTE group, plasma FⅦa levelsin FⅦ gene R/R genotype were statistically higher than R/Q and Q/Q genotype (P <0.05).③Multifactor logistic regression analysis showed that, after adjusting for age, gender,smoking history, dyslipidemia, hypertension, diabetes, and FⅦgenotype, plasma FⅦalevels(OR=0.152,95%CI1.086-1.247, P=0.000), Fibrinogen(OR=2.858,95%CI1.675-4.879,P=0.000) and Smoking (OR=1.623,95%CI1.039-2.009,P=0.001) wereindependent risk factors for VTE patients. Conclusion:The plasma FⅦa levels was higherin VTE patients compared to normal population, and high plasma FⅦa levels may be a common risk factor for VTE. The FⅦ R353Q polymorphism may not be an independentrisk factor for VTE patients.

Related Dissertations

  1. Study of Mutation and Breeding of Griseofulvin Produccing Strain FS80,TQ927
  2. Breeding of Fungal α-amylase High-producing Strain by Genome Shuffling,TQ925
  3. Study on the Breeding of High Efficient Detoxification Strains and Suggestion Parameters of Solid Fermentation on Cottonseed Meal,S816.6
  4. Incidence and Mechanisms of Insecticide Resistances to Organophosphates and Carbamates in Colorado Potato Beetle, Leptinotarsa Decemlineata (Say),S435.32
  5. Screening, Bio-Characteristics and Biopulping Application of a High Pectin-Degrading Baeterial Strain by Ultraviolet-Ray Mutation,TS713
  6. Preliminary Studies on Constructing Brassica Napus L Mutant Library by EMS Inducement,S565.4
  7. Research on the Mutation Breeding of Flavomycin and Regulation of Fermentation Techniques,TQ920.6
  8. The Dynamic Changes of D-dimer Following Venous Thromboembolismin Rats,R543.6
  9. Analysis of Clinical Characteristics in 275 Hospitalized Patients with Venous Thromboembolism,R543.6
  10. Research and Application on Ant Colony Clustering Based on Reinforcement Learning,TP18
  11. Study on the sRNA Coding Gene YigP in Escherichia Coli,Q933
  12. The Study on the Mutation of Mitofusin 2 Trigger the Apoptosis of VSMC,R541.4
  13. Mutations in Nr5a1, PIN1 Associated with Idiopathic Hypogonadotropic Hypogonadism,R588
  14. The Primary Study of Coagulopathy in Lung Cancer Patients,R734.2
  15. Inflammatory and coagulation factors and CRP1059G / C gene polymorphism and pulmonary thromboembolism associated,R563.5
  16. Detecting the Promoter Polymorphisms of the IL-6 Gene and Its Association with Venous Thromboembolism (VTE),R543.6
  17. Screening of Mutated Sporotrichum Thermophile with High Endoglucanase Activity,Q93
  18. Mutation Analysis of p63 Gene in the First Chinese Family with ADULT Syndrome,R758.5
  19. A Novel Mutation of Gene Runx2 in Chinese Patients with Delayed Tooth Eruption,R781.2
  20. Confirmation of the G3635A Mutation in the Mitochondrial ND1 Gene as Causative in Leber’s Hereditary Optic Neuropathy,R774.6
  21. The Role of Thyroid Hormone and Its Receptor TRβ Gene Mutation in Pathogenesis and Prognosis of Thyroid Cancer,R736.1

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Vascular disease > Venous disease
© 2012 www.DissertationTopic.Net  Mobile