Dissertation > Excellent graduate degree dissertation topics show

Epidemiology and Risk Factors for Infections after Liver Transplantation

Author: XuJun
Tutor: ZhengShuSen
School: Zhejiang University
Course: Surgery
Keywords: liver transplantation infection risk factors
CLC: R657.3
Type: Master's thesis
Year: 2012
Downloads: 44
Quote: 0
Read: Download Dissertation

Abstract


Introduction:Infection is a major cause of post-transplant mortality in liver transplant (LT) recipients. This study seeks to identify the epidemiology and its evolving trends to benefit prophylactic and empiric treatment for liver transplant recipients.Methods:We retrospectively analyzed the frequency and characteristics of post-transplant infections in564recipients, who underwent liver transplantation between January1st,2004and December31st,2009in our center, and evaluated the risk factors of post-transplantation infection.Results:Overall,394patients got at least one kind of infections within the hospitalization time following LT, mobility69.9%; Of the564patients transplanted,41patients (7.3%) died. The mean hospitalization time was42±22(range0～147d). A considerable decrease of incidence rate occurred from2004to2009, and the mortality fluctuated around about5%and had a slight decrease from2004to2009. In total,1771pathogens were isolated. Gram-positive bacteria, Gram-negative bacteria and fungal accounted for28%(496),57.1%(1011) and14.9%(264). The most frequent pathogens were Staphylococcus (18.2%), Stenotrophomonas maltophilia (9.8%), Acinetobacter baumannii (6.6%), Enterococcus (6.0%) and Pseudomonas aeruginosa (5.3%). Kaplan-Meier1-year survival curves showed that patients with infection had a significantly lower cumulative survival rate than whose without infection (82.7%versus90.0%, P<0.01). Multivariate analysis revealed that age>60years (P=0.010), severe hepatitis (P=0.030), cadaveric donor (P=0.000) and post-LT bile leakage (P=0.014) were independent risk factors for infection within hospitalization time after LT. And post-LT bile leakage still need to be identified (95%CI=1.675-108.253, P=0.014). While hepatic carcinoma (P=0.002) showed protective effect compared with tumor-free group for infection.Conclusion:Infection is a frequent complication during hospitalization after LT, and the mortality of infection is still a big challenge for post-LT treatment. Early detection and treatment of infections is necessary to getting a better outcome of patients post-LT. We suggest clinicians improve patients’condition before liver transplantation, especially for patients aged more than60years and those suffered from severe hepatitis.

Related Dissertations

  1. Research and Analysis of Postcholecystectomy Diarrhoea (PCD) in Chronic Calculous Cholecystitis,R657.4
  2. Professor Zhang Shuwen academic thinking,and 59 cases of Chinese and Western medicine combined with clinical research for diagnosis and treatment of acute pancreatitis,R249.2
  3. Study on Sorghum Sudanense Leaf Spot Caused by Bipolaris Sorghicola,S435.4
  4. The Empirical Research of the Important Factors of the Financial Risks of Chinese A-share Construction Enterprises Market,F426.92
  5. A Comparative Study of prawns, crabs, Spiroplasma disease immunohistochemistry and pathology,S945
  6. Treatment of Device-Related Infection in Rabitts by High Requency Electric,R687.3
  7. Research Oven Based on Keeping Cakes’ Original Cuisine,TS210.3
  8. Retrospective Analysis of Infectious Precipitating Factors in Cirrhosis with Hepatic Encephalopathy,R575.2
  9. Analysis of the Risk Factors Affecting Kidney Dysfunction Among Hospitalized Patients with Chronic Kidney Disease (an Analysis of 348 Cases),R692
  10. Analysis of Hand-foot-mouth Disease Prevalence and Influencing Factors in High Risk Group in Hefei City,R725.1
  11. High School Teaching of Classical Literature and the Contemporary High School Students Personality Cultivation,G633.3
  12. Epidemiology of Helicobacter Pylori Infection and Associated Factors among Workers in Dalian Port Group,R181.3
  13. Differential Diagnosis Significance in Patients with Chest Tightness Chest Pain and Analysis for the Risk Factors of Airflow Limitation,R54
  14. Study on Risk Factors and Clinical Characteristics of First Acute Myocardial Infarction in the Young and Old Patients,R542.22
  15. The Clinical Study of ω-3 Polyunsaturated Fatty Acids in Severe Brain Injury Complicated by Lung Infection,R651.1
  16. Clinical Features and Prognostic Factor Analysis of Elderly Community-acquired Pneumonia,R563.1
  17. Analysis of Death-related Risk Factors in Fulminant Acute Pancreatitis,R657.51
  18. Measure the Volume of Olfactory Bulbs by Mri and Study the Correlation of Olfactory Function and Olfactory Bulb in Post-traumatic and Post-infectious Patients,R651.1
  19. Research of Risk Factors, Predictors and Prevention of Pancreatic Fistula after Pancreatoduodenectomy,R656
  20. A Case-control Study on the Relative Risk Factors of Adenomyosis,R711.71
  21. Diagnosis Value of Cytokine Levels and TB-Ab in Serum in Children Tuberculosis and Latent Tuberculosis Infection,R725.1

CLC: > Medicine, health > Surgery > Of surgery > Abdominal surgery > Liver and liver tube
© 2012 www.DissertationTopic.Net  Mobile